Anti-GLMN Antibody (CAB12025)
- SKU:
- CAB12025
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-GLMN Antibody |
| 抗体コード: | CAB12025 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 405-594 of human GLMN (NP_444504.1). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse |
| ポジティブサンプル: | A-549, U-87MG, HepG2, Mouse testis |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 405-594 of human GLMN (NP_444504.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | RCLL NTSN HSGV EAFI IQNI KNQI DMSL KRTR NNKW FTGP QLIS LLDL VLFL PEGA ETDL LQNS DRIM ASLN LLRY LVIK DNEN DNQT GLWT ELGN IENN FLKP LHIG LNMS KAHY EAEI KNSQ EAQK SKDL CSIT VSGE EIPN MPPE MQLK VLHS ALFT FDLI ESVL ARVE ELIE IKTK STSE ENIG IK |
| 遺伝子ID: | 11146 |
| Uniprot: | Q92990 |
| セルラーロケーション: | |
| 計算された分子量: | 48kDa/68kDa |
| 観察された分子量: | 68kDa |
| 同義語: | GLMN, FAP, FAP48, FAP68, FKBPAP, GLML, GVM, VMGLOM, glomulin |
| バックグラウンド: | This gene encodes a phosphorylated protein that is a member of a Skp1-Cullin-F-box-like complex. The protein is essential for normal development of the vasculature and mutations in this gene have been associated with glomuvenous malformations, also called glomangiomas. Multiple splice variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | GLMN: Essential for normal development of the vasculature. May represent a naturally occurring ligand of the immunophilins FKBP59 and FKBP12. May function as an membrane anchoring protein. Isoform 1 may stimulate the p70S6K pathway. Isoform 2 may inhibit cell proliferation and increase IL2 production. Defects in GLMN are the cause of glomuvenous malformations (GVMs). GVMs are characterized by the presence of smooth-muscle-like glomus cells in the media surrounding distended vascular lumens. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Cytokine Chromosomal Location of Human Ortholog: 1p22.1 Cellular Component: Cul2-RING ubiquitin ligase complex; cullin-RING ubiquitin ligase complex Molecular Function:hepatocyte growth factor receptor binding; protein binding; ubiquitin protein ligase binding; ubiquitin-protein ligase inhibitor activity Biological Process: muscle cell differentiation; negative regulation of T cell proliferation; positive regulation of cytokine secretion; positive regulation of interleukin-2 biosynthetic process; positive regulation of phosphorylation; regulation of gene expression, epigenetic; regulation of proteasomal ubiquitin-dependent protein catabolic process; vasculogenesis Disease: Glomuvenous Malformations |
| NCBI Summary: | This gene encodes a phosphorylated protein that is a member of a Skp1-Cullin-F-box-like complex. The protein is essential for normal development of the vasculature and mutations in this gene have been associated with glomuvenous malformations, also called glomangiomas. Multiple splice variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2016] |
| UniProt Code: | Q92990 |
| NCBI GenInfo Identifier: | 38372884 |
| NCBI Gene ID: | 11146 |
| NCBI Accession: | Q92990.2 |
| UniProt Secondary Accession: | Q92990,Q5VVC3, Q9BVE8, |
| UniProt Related Accession: | Q92990 |
| Molecular Weight: | 48,166 Da |
| NCBI Full Name: | Glomulin |
| NCBI Synonym Full Names: | glomulin, FKBP associated protein |
| NCBI Official Symbol: | GLMN |
| NCBI Official Synonym Symbols: | FAP; GVM; GLML; FAP48; FAP68; FKBPAP; VMGLOM |
| NCBI Protein Information: | glomulin |
| UniProt Protein Name: | Glomulin |
| UniProt Synonym Protein Names: | FK506-binding protein-associated protein; FAP; FKBP-associated protein |
| Protein Family: | Glomulin |
| UniProt Gene Name: | GLMN |
| UniProt Entry Name: | GLMN_HUMAN |
 | Western blot analysis of extracts of various cell lines, using GLMN antibody (CAB12025) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s. |
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