Anti-GLI2 Antibody (CAB16863)
- SKU:
- CAB16863
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
Frequently bought together:
Description
| 抗体名: | Anti-GLI2 Antibody |
| 抗体コード: | CAB16863 |
| 抗体サイズ: | 20uL, 50 uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse |
| 宿主種: | Rabbit |
| 免疫原: | A synthetic peptide corresponding to a sequence within amino acids 50-150 of human GLI2 (NP_005261.2). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse |
| ポジティブサンプル: |
| 免疫原: | A synthetic peptide corresponding to a sequence within amino acids 50-150 of human GLI2 (NP_005261.2). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | VPQH LLPP FHAP LPID MRHQ EGRY HYEP HSVH GVHG PPAL SGSP VISD ISLI RLSP HPAG PGES PFNA PHPY VNPH MEHY LRSV HSSP TLSM ISAA RGLS P |
| 遺伝子ID: | 2736 |
| Uniprot: | P10070 |
| セルラーロケーション: | |
| 計算された分子量: | 168kDa |
| 観察された分子量: | Refer to figures |
| 同義語: | GLI2, CJS, HPE9, PHS2, THP1, THP2, Gli2 |
| バックグラウンド: | This gene encodes a protein which belongs to the C2H2-type zinc finger protein subclass of the Gli family. Members of this subclass are characterized as transcription factors which bind DNA through zinc finger motifs. These motifs contain conserved H-C links. Gli family zinc finger proteins are mediators of Sonic hedgehog (Shh) signaling and they are implicated as potent oncogenes in the embryonal carcinoma cell. The protein encoded by this gene localizes to the cytoplasm and activates patched Drosophila homolog (PTCH) gene expression. It is also thought to play a role during embryogenesis. The encoded protein is associated with several phenotypes- Greig cephalopolysyndactyly syndrome, Pallister-Hall syndrome, preaxial polydactyly type IV, postaxial polydactyly types A1 and B. |
| UniProt Protein Function: | Functions as transcription regulator in the hedgehog (Hh) pathway (PubMed:18455992). Functions as transcriptional activator (PubMed:9557682, PubMed:19878745, PubMed:24311597). May also function as transcriptional repressor. Requires STK36 for full transcriptional activator activity. Required for normal embryonic development (PubMed:15994174, PubMed:20685856). |
| NCBI Summary: | This gene encodes a protein which belongs to the C2H2-type zinc finger protein subclass of the Gli family. Members of this subclass are characterized as transcription factors which bind DNA through zinc finger motifs. These motifs contain conserved H-C links. Gli family zinc finger proteins are mediators of Sonic hedgehog (Shh) signaling and they are implicated as potent oncogenes in the embryonal carcinoma cell. The protein encoded by this gene localizes to the cytoplasm and activates patched Drosophila homolog (PTCH) gene expression. It is also thought to play a role during embryogenesis. The encoded protein is associated with several phenotypes- Greig cephalopolysyndactyly syndrome, Pallister-Hall syndrome, preaxial polydactyly type IV, postaxial polydactyly types A1 and B. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P10070 |
| NCBI GenInfo Identifier: | 215274258 |
| NCBI Gene ID: | 2736 |
| NCBI Accession: | P10070.4 |
| UniProt Related Accession: | P10070 |
| Molecular Weight: | 168kDa |
| NCBI Full Name: | Zinc finger protein GLI2 |
| NCBI Synonym Full Names: | GLI family zinc finger 2 |
| NCBI Official Symbol: | GLI2 |
| NCBI Official Synonym Symbols: | CJS; HPE9; PHS2; THP1; THP2 |
| NCBI Protein Information: | zinc finger protein GLI2 |
| UniProt Protein Name: | Zinc finger protein GLI2 |
| UniProt Synonym Protein Names: | GLI family zinc finger protein 2; Tax helper protein |
| Protein Family: | Zinc finger protein |
| UniProt Gene Name: | GLI2 |
| UniProt Entry Name: | GLI2_HUMAN |