Anti-GJB4 Antibody (CAB9888)
- SKU:
- CAB9888
- Product type:
- Antibody
- Application:
- WB
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-GJB4 Antibody |
| 抗体コード: | CAB9888 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | A synthetic peptide corresponding to a sequence within amino acids 100-200 of human GJB4 (NP_694944.1). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Mouse, Rat |
| ポジティブサンプル: | Mouse liver, Rat skin |
| 免疫原: | A synthetic peptide corresponding to a sequence within amino acids 100-200 of human GJB4 (NP_694944.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | ERER KHHL KHGP NAPS LYDN LSKK RGGL WWTY LLSL IFKA AVDA GFLY IFHR LYKD YDMP RVVA CSVE PCPH TVDC YISR PTEK KVFT YFMV TTAA ICIL L |
| 遺伝子ID: | 127534 |
| Uniprot: | Q9NTQ9 |
| セルラーロケーション: | Cell junction, Cell membrane, Multi-pass membrane protein, gap junction |
| 計算された分子量: | 30kDa |
| 観察された分子量: | 30kDa |
| 同義語: | GJB4, CX30.3, EKV, EKVP2 |
| バックグラウンド: | This gene encodes a transmembrane connexin protein that is a component of gap junctions. Mutations in this gene have been associated with erythrokeratodermia variabilis, progressive symmetric erythrokeratoderma and hearing impairment. |
| UniProt Protein Function: | GJB4: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. Defects in GJB4 are a cause of erythrokeratodermia variabilis (EKV). EKV is a genodermatosis characterized by the appearance of two independent skin lesions: transient figurate erythematous patches and hyperkeratosis that is usually localized but occasionally occurs in its generalized form. Clinical presentation varies significantly within a family and from one family to another. Palmoplantar keratoderma is present in around 50% of cases. Belongs to the connexin family. Beta-type (group I) subfamily. |
| UniProt Protein Details: | Protein type:Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass Chromosomal Location of Human Ortholog: 1p34.3 Cellular Component: cell junction; nucleolus; nucleus Disease: Erythrokeratodermia Variabilis Et Progressiva |
| NCBI Summary: | This gene encodes a transmembrane connexin protein that is a component of gap junctions. Mutations in this gene have been associated with erythrokeratodermia variabilis, progressive symmetric erythrokeratoderma and hearing impairment. [provided by RefSeq, Dec 2009] |
| UniProt Code: | Q9NTQ9 |
| NCBI GenInfo Identifier: | 12229761 |
| NCBI Gene ID: | 127534 |
| NCBI Accession: | Q9NTQ9.1 |
| UniProt Secondary Accession: | Q9NTQ9,B3KQ82, |
| UniProt Related Accession: | Q9NTQ9 |
| Molecular Weight: | 30kDa |
| NCBI Full Name: | Gap junction beta-4 protein |
| NCBI Synonym Full Names: | gap junction protein beta 4 |
| NCBI Official Symbol: | GJB4 |
| NCBI Official Synonym Symbols: | EKV; CX30.3 |
| NCBI Protein Information: | gap junction beta-4 protein |
| UniProt Protein Name: | Gap junction beta-4 protein |
| UniProt Synonym Protein Names: | Connexin-30.3; Cx30.3 |
| Protein Family: | Gap junction beta-4 protein |
| UniProt Gene Name: | GJB4 |
 | Western blot analysis of extracts of various cell lines, using GJB4 Antibody (CAB9888) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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