Anti-GIPR Antibody (CAB9816)
- SKU:
- CAB9816
- Product type:
- Antibody
- Application:
- WB
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-GIPR Antibody |
| 抗体コード: | CAB9816 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IHC |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 22-138 of human GIPR (NP_000155.1). |
| 申し込み: | WB IHC |
| 推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | K-562, Mouse liver, Rat heart, Rat brain |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 22-138 of human GIPR (NP_000155.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | RAET GSKG QTAG ELYQ RWER YRRE CQET LAAA EPPS GLAC NGSF DMYV CWDY AAPN ATAR ASCP WYLP WHHH VAAG FVLR QCGS DGQW GLWR DHTQ CENP EKNE AFLD QRLI LERL Q |
| 遺伝子ID: | 2696 |
| Uniprot: | P48546 |
| セルラーロケーション: | Cell membrane, Multi-pass membrane protein |
| 計算された分子量: | 48kDa/49kDa/53kDa |
| 観察された分子量: | 45kDa |
| 同義語: | GIPR, PGQTL2 |
| バックグラウンド: | This gene encodes a G-protein coupled receptor for gastric inhibitory polypeptide (GIP), which was originally identified as an activity in gut extracts that inhibited gastric acid secretion and gastrin release, but subsequently was demonstrated to stimulate insulin release in the presence of elevated glucose. Mice lacking this gene exhibit higher blood glucose levels with impaired initial insulin response after oral glucose load. Defect in this gene thus may contribute to the pathogenesis of diabetes. |
| UniProt Protein Function: | GIPR: This is a receptor for GIP. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 2 family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, multi-pass; GPCR, family 2; Membrane protein, integral; Receptor, GPCR Chromosomal Location of Human Ortholog: 19q13.3 Cellular Component: plasma membrane Molecular Function:transmembrane receptor activity Biological Process: adenylate cyclase activation; generation of precursor metabolites and energy; regulation of insulin secretion; response to nutrient |
| NCBI Summary: | This gene encodes a G-protein coupled receptor for gastric inhibitory polypeptide (GIP), which was originally identified as an activity in gut extracts that inhibited gastric acid secretion and gastrin release, but subsequently was demonstrated to stimulate insulin release in the presence of elevated glucose. Mice lacking this gene exhibit higher blood glucose levels with impaired initial insulin response after oral glucose load. Defect in this gene thus may contribute to the pathogenesis of diabetes. [provided by RefSeq, Oct 2011] |
| UniProt Code: | P48546 |
| NCBI GenInfo Identifier: | 1346133 |
| NCBI Gene ID: | 2696 |
| NCBI Accession: | P48546.1 |
| UniProt Secondary Accession: | P48546,Q14401, Q16400, Q52M04, Q9UPI1, B7WP14, B7ZKQ0 |
| UniProt Related Accession: | P48546 |
| Molecular Weight: | 49,062 Da |
| NCBI Full Name: | Gastric inhibitory polypeptide receptor |
| NCBI Synonym Full Names: | gastric inhibitory polypeptide receptor |
| NCBI Official Symbol: | GIPR |
| NCBI Official Synonym Symbols: | PGQTL2 |
| NCBI Protein Information: | gastric inhibitory polypeptide receptor |
| UniProt Protein Name: | Gastric inhibitory polypeptide receptor |
| UniProt Synonym Protein Names: | Glucose-dependent insulinotropic polypeptide receptor |
| Protein Family: | Gastric inhibitory polypeptide receptor |
| UniProt Gene Name: | GIPR |
| UniProt Entry Name: | GIPR_HUMAN |
 | Western blot analysis of extracts of various cell lines, using GIPR antibody (CAB9816) at 1:1000 dilution._Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution._Lysates/proteins: 25ug per lane._Blocking buffer: 3% nonfat dry milk in TBST._Detection: ECL Enhanced Kit (RM00021)._Exposure time: 90s. |
 | Immunohistochemistry of paraffin-embedded rat brain using GIPR Rabbit pAb (CAB9816) at dilution of 1:200 (40x lens). |
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