Anti-GGA1 Antibody (CAB17126)
- SKU:
- CAB17126
- Product type:
- Antibody
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
Frequently bought together:
Description
| 抗体名: | Anti-GGA1 Antibody |
| 抗体コード: | CAB17126 |
| 抗体サイズ: | 20uL, 50 uL |
| 申し込み: | WB |
| 反応性: | Mouse |
| 宿主種: | Rabbit |
| 免疫原: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human GGA1 (NP_001001560.1). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Mouse |
| ポジティブサンプル: |
| 免疫原: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human GGA1 (NP_001001560.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | MEPA MEPE TLEA RINR ATNP LNKE LDWA SING FCEQ LNED FEGP PLAT RLLA HKIQ SPQE WEAI QALT VLET CMKS CGKR FHDE VGKF RFLN ELIK VVSP |
| 遺伝子ID: | 26088 |
| Uniprot: | Q9UJY5 |
| セルラーロケーション: | |
| 計算された分子量: | 9kDa/61kDa/62kDa/66kDa/70kDa/72kDa |
| 観察された分子量: | Refer to figures |
| 同義語: | GGA1 |
| バックグラウンド: | This gene encodes a member of the Golgi-localized, gamma adaptin ear-containing, ARF-binding (GGA) protein family. Members of this family are ubiquitous coat proteins that regulate the trafficking of proteins between the trans-Golgi network and the lysosome. These proteins share an amino-terminal VHS domain which mediates sorting of the mannose 6-phosphate receptors at the trans-Golgi network. They also contain a carboxy-terminal region with homology to the ear domain of gamma-adaptins. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | GGA1: Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF- dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (AC-LL) motif. Belongs to the GGA protein family. 5 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Vesicle; Adaptor/scaffold Chromosomal Location of Human Ortholog: 22q13.31 Cellular Component: nucleoplasm; Golgi apparatus; clathrin adaptor complex; intracellular membrane-bound organelle; membrane; endosome membrane Molecular Function:protein binding Biological Process: vesicle-mediated transport; intracellular protein transport; positive regulation of protein catabolic process |
| NCBI Summary: | This gene encodes a member of the Golgi-localized, gamma adaptin ear-containing, ARF-binding (GGA) protein family. Members of this family are ubiquitous coat proteins that regulate the trafficking of proteins between the trans-Golgi network and the lysosome. These proteins share an amino-terminal VHS domain which mediates sorting of the mannose 6-phosphate receptors at the trans-Golgi network. They also contain a carboxy-terminal region with homology to the ear domain of gamma-adaptins. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9UJY5 |
| NCBI GenInfo Identifier: | 14548066 |
| NCBI Gene ID: | 26088 |
| NCBI Accession: | Q9UJY5.1 |
| UniProt Related Accession: | Q9UJY5 |
| Molecular Weight: | |
| NCBI Full Name: | ADP-ribosylation factor-binding protein GGA1 |
| NCBI Synonym Full Names: | golgi associated, gamma adaptin ear containing, ARF binding protein 1 |
| NCBI Official Symbol: | GGA1 |
| NCBI Protein Information: | ADP-ribosylation factor-binding protein GGA1 |
| UniProt Protein Name: | ADP-ribosylation factor-binding protein GGA1 |
| UniProt Synonym Protein Names: | Gamma-adaptin-related protein 1; Golgi-localized, gamma ear-containing, ARF-binding protein 1 |
| Protein Family: | ADP-ribosylation factor-binding protein |
| UniProt Gene Name: | GGA1 |
| UniProt Entry Name: | GGA1_HUMAN |