Anti-GEMIN8 Antibody (CAB13708)
- SKU:
- CAB13708
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Frequently bought together:
Description
| 抗体名: | Anti-GEMIN8 Antibody |
| 抗体コード: | CAB13708 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-242 of human GEMIN8 (NP_060326.1). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human |
| ポジティブサンプル: | A-549, HT-29, HepG2 |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-242 of human GEMIN8 (NP_060326.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | MAAV KAST SKAT RPWY SHPV YARY WQHY HQAM AWMQ SHHN AYRK AVES CFNL PWYL PSAL LPQS SYDN EAAY PQSF YDHH VAWQ DYPC SSSH FRRS GQHP RYSS RIQA STKE DQAL SKEE EMET ESDA EVEC DLSN MEIT EELR QYFA ETER HREE RRRQ QQLD AERL DSYV NADH DLYC NTRR SVEA PTER PGER RQAE MKRL YGDS AAKI QAME AAVQ LSFD KHCD RKQP KYWP VIPL KF |
| 遺伝子ID: | 54960 |
| Uniprot: | Q9NWZ8 |
| セルラーロケーション: | Cytoplasm, Nucleus, gem |
| 計算された分子量: | 28kDa |
| 観察された分子量: | 35kDa |
| 同義語: | GEMIN8, FAM51A1 |
| バックグラウンド: | The protein encoded by this gene is part of the SMN complex, which is necessary for spliceosomal snRNP assembly in the cytoplasm and pre-mRNA splicing in the nucleus. The encoded protein binds to both SMN1 and the GEMIN6/GEMIN7 heterodimer, mediating their interaction. This protein is found in nuclear Gemini of Cajal bodies (gems) and in the cytoplasm. Three transcript variants encoding the same protein have been found for this gene. |
| UniProt Protein Function: | GEMIN8: The SMN complex plays an essential role in spliceosomal snRNP assembly in the cytoplasm and is required for pre-mRNA splicing in the nucleus. |
| UniProt Protein Details: | Protein type:RNA splicing; RNA-binding Chromosomal Location of Human Ortholog: Xp22.2 Cellular Component: cytoplasm; cytosol; nucleus; SMN complex Molecular Function:protein binding Biological Process: spliceosomal snRNP biogenesis |
| NCBI Summary: | The protein encoded by this gene is part of the SMN complex, which is necessary for spliceosomal snRNP assembly in the cytoplasm and pre-mRNA splicing in the nucleus. The encoded protein binds to both SMN1 and the GEMIN6/GEMIN7 heterodimer, mediating their interaction. This protein is found in nuclear Gemini of Cajal bodies (gems) and in the cytoplasm. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, May 2010] |
| UniProt Code: | Q9NWZ8 |
| NCBI GenInfo Identifier: | 52782795 |
| NCBI Gene ID: | 54960 |
| NCBI Accession: | Q9NWZ8.1 |
| UniProt Secondary Accession: | Q9NWZ8,Q2LJ66, Q6ZV27, C4AMC4, |
| UniProt Related Accession: | Q9NWZ8 |
| Molecular Weight: | 28,637 Da |
| NCBI Full Name: | Gem-associated protein 8 |
| NCBI Synonym Full Names: | gem nuclear organelle associated protein 8 |
| NCBI Official Symbol: | GEMIN8 |
| NCBI Official Synonym Symbols: | FAM51A1 |
| NCBI Protein Information: | gem-associated protein 8 |
| UniProt Protein Name: | Gem-associated protein 8 |
| UniProt Synonym Protein Names: | Protein FAM51A1 |
| Protein Family: | Gem-associated protein |
| UniProt Gene Name: | GEMIN8 |
| UniProt Entry Name: | GEMI8_HUMAN |
 | Western blot analysis of extracts of various cell lines, using GEMIN8 antibody (CAB13708) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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