Anti-GEMIN5 Antibody (CAB17125)
- SKU:
- CAB17125
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
Frequently bought together:
Description
| 抗体名: | Anti-GEMIN5 Antibody |
| 抗体コード: | CAB17125 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IHC |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 750-950 of human GEMIN5 (NP_056280.2). |
| 申し込み: | WB IHC |
| 推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:100 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | HeLa |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 750-950 of human GEMIN5 (NP_056280.2). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | RTPV KLES IDGN EEES MKEN SGPV ENGV SDQE GEEQ AREP ELPC GLAP AVSR EPVI CTPV SSGF EKSK VTIN NKVI LLKK EPPK EKPE TLIK KRKA RSLL PLST SLDH RSKE ELHQ DCLV LATA KHSR ELNE DVSA DVEE RFHL GLFT DRAT LYRM IDIE GKGH LENG HPEL FHQL MLWK GDLK GVLQ TAAE RGEL TDNL V |
| 遺伝子ID: | 25929 |
| Uniprot: | Q8TEQ6 |
| セルラーロケーション: | |
| 計算された分子量: | 168kDa |
| 観察された分子量: | 180kDa |
 | Western blot - GEMIN5 Rabbit pAb (CAB17125) |
| 同義語: | GEMIN5, GEMIN-5 |
| バックグラウンド: | This gene encodes a WD repeat protein that is a component of the survival of motor neurons (SMN) complex. The SMN complex plays a critical role in mRNA splicing through the assembly of spliceosomal small nuclear ribonucleoproteins (snRNPs), and may also mediate the assembly and transport of other classes of ribonucleoproteins. The encoded protein is the snRNA-binding component of the SMN complex. Dysregulation of this gene may play a role in alternative mRNA splicing and tumor cell motility. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. |
| UniProt Protein Function: | GEMIN5: the snRNA-binding protein of the SMN complex. The SMN complex plays an essential role in spliceosomal snRNP assembly in the cytoplasm and is required for pre-mRNA splicing in the nucleus. Found both in the nucleoplasm and in nuclear bodies called gems (Gemini of Cajal bodies) that are often in proximity to Cajal (coiled) bodies. Also found in the cytoplasm. |
| UniProt Protein Details: | Protein type:RNA splicing; Nuclear receptor co-regulator; RNA-binding; RNA processing Chromosomal Location of Human Ortholog: 5q33.2 Cellular Component: nucleoplasm; nuclear body; membrane; cytoplasm; SMN complex; cytosol; nucleus Molecular Function:protein binding; snRNA binding Biological Process: nuclear mRNA splicing, via spliceosome; spliceosomal snRNP biogenesis; gene expression; protein complex assembly |
| NCBI Summary: | This gene encodes a WD repeat protein that is a component of the survival of motor neurons (SMN) complex. The SMN complex plays a critical role in mRNA splicing through the assembly of spliceosomal small nuclear ribonucleoproteins (snRNPs), and may also mediate the assembly and transport of other classes of ribonucleoproteins. The encoded protein is the snRNA-binding component of the SMN complex. Dysregulation of this gene may play a role in alternative mRNA splicing and tumor cell motility. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011] |
| UniProt Code: | Q8TEQ6 |
| NCBI GenInfo Identifier: | 356461016 |
| NCBI Gene ID: | 25929 |
| NCBI Accession: | NP_001239085.1 |
| UniProt Secondary Accession: | Q8TEQ6,Q14CV0, Q8WWV4, Q969W4, Q9H9K3, Q9UFI5, |
| UniProt Related Accession: | Q8TEQ6 |
| Molecular Weight: | 168,589 Da |
| NCBI Full Name: | gem-associated protein 5 isoform 2 |
| NCBI Synonym Full Names: | gem (nuclear organelle) associated protein 5 |
| NCBI Official Symbol: | GEMIN5 |
| NCBI Official Synonym Symbols: | GEMIN-5 |
| NCBI Protein Information: | gem-associated protein 5 |
| UniProt Protein Name: | Gem-associated protein 5 |
| Protein Family: | Gem-associated protein |
| UniProt Gene Name: | GEMIN5 |
| UniProt Entry Name: | GEMI5_HUMAN |