Anti-GDF2 Antibody (CAB10537)
- SKU:
- CAB10537
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cardiovascular
Description
| 抗体名: | Anti-GDF2 Antibody |
| 抗体コード: | CAB10537 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 320-429 of human GDF2 (NP_057288.1). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | Mouse pancreas, Mouse skeletal muscle, Rat skeletal muscle |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 320-429 of human GDF2 (NP_057288.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | SAGA GSHC QKTS LRVN FEDI GWDS WIIA PKEY EAYE CKGG CFFP LADD VTPT KHAI VQTL VHLK FPTK VGKA CCVP TKLS PISV LYKD DMGV PTLK YHYE GMSV AECG CR |
| 遺伝子ID: | 2658 |
| Uniprot: | Q9UK05 |
| セルラーロケーション: | Secreted |
| 計算された分子量: | 47kDa |
| 観察された分子量: | 47kDa |
| 同義語: | GDF2, BMP-9, BMP9, HHT5 |
| バックグラウンド: | The protein encoded by this gene is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. Studies in rodents suggest that this protein plays a role in the adult liver and in differentiation of cholinergic central nervous system neurons. Mutations in this gene are associated with hereditary hemorrhagic telangiectasia. |
| UniProt Protein Function: | GDF2: Could be involved in bone formation. Belongs to the TGF-beta family. |
| UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 10q11.22 Cellular Component: extracellular space Molecular Function:cytokine activity; protein binding; transforming growth factor beta receptor binding Biological Process: activin receptor signaling pathway; angiogenesis; blood vessel morphogenesis; BMP signaling pathway; cartilage development; cell development; cellular iron ion homeostasis; negative regulation of angiogenesis; negative regulation of blood vessel endothelial cell migration; negative regulation of cell growth; negative regulation of DNA replication; negative regulation of endothelial cell proliferation; ossification; patterning of blood vessels; positive regulation of angiogenesis; positive regulation of endothelial cell proliferation; positive regulation of interleukin-8 production; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; regulation of apoptosis; regulation of MAPKKK cascade Disease: Telangiectasia, Hereditary Hemorrhagic, Type 5 |
| NCBI Summary: | This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein regulates cartilage and bone development, angiogenesis and differentiation of cholinergic central nervous system neurons. Mutations in this gene are associated with hereditary hemorrhagic telangiectasia. [provided by RefSeq, Jul 2016] |
| UniProt Code: | Q9UK05 |
| NCBI GenInfo Identifier: | 13124266 |
| NCBI Gene ID: | 2658 |
| NCBI Accession: | Q9UK05.1 |
| UniProt Secondary Accession: | Q9UK05,Q5VSQ9, Q9Y571, |
| UniProt Related Accession: | Q9UK05 |
| Molecular Weight: | 47kDa |
| NCBI Full Name: | Growth/differentiation factor 2 |
| NCBI Synonym Full Names: | growth differentiation factor 2 |
| NCBI Official Symbol: | GDF2 |
| NCBI Official Synonym Symbols: | BMP9; HHT5; BMP-9 |
| NCBI Protein Information: | growth/differentiation factor 2 |
| UniProt Protein Name: | Growth/differentiation factor 2 |
| UniProt Synonym Protein Names: | Bone morphogenetic protein 9; BMP-9 |
| Protein Family: | Growth/differentiation factor |
| UniProt Gene Name: | GDF2 |
 | Western blot analysis of extracts of various cell lines, using GDF2 antibody (CAB10537) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5s. |