Anti-GDF15 Antibody (CAB0185)
- SKU:
- CAB0185
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-GDF15 Antibody |
| 抗体コード: | CAB0185 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IHC IP |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 49-308 of human GDF15 (NP_004855.2). |
| 申し込み: | WB IHC IP |
| 推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:100 IP 1:50 - 1:200 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | PC-3, HT-1080 |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 49-308 of human GDF15 (NP_004855.2). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | EDSR FREL RKRY EDLL TRLR ANQS WEDS NTDL VPAP AVRI LTPE VRLG SGGH LHLR ISRA ALPE GLPE ASRL HRAL FRLS PTAS RSWD VTRP LRRQ LSLA RPQA PALH LRLS PPPS QSDQ LLAE SSSA RPQL ELHL RPQA ARGR RRAR ARNG DHCP LGPG RCCR LHTV RASL EDLG WADW VLSP REVQ VTMC IGAC PSQF RAAN MHAQ IKTS LHRL KPDT VPAP CCVP ASYN PMVL IQKT DTGV SLQT YDDL LAKD CHCI |
| 遺伝子ID: | 9518 |
| Uniprot: | Q99988 |
| セルラーロケーション: | Secreted |
| 計算された分子量: | 34kDa |
| 観察された分子量: | 35KDa |
| 同義語: | GDF15, GDF-15, MIC-1, MIC1, NAG-1, PDF, PLAB, PTGFB |
| バックグラウンド: | The protein encoded by this gene belongs to the transforming growth factor-beta (TGF-beta) family. The protein is expressed in a broad range of cell types, acts as a pleiotropic cytokine and is involved in the stress reponse program of cells after cellular injury. Increased protein levels are associated with disease states such as tissue hypoxia, inflammation, acute injury and oxidative stress. |
| UniProt Protein Function: | GDF15: disulfide-linked. Belongs to the TGF-beta family. |
| UniProt Protein Details: | Protein type:Secreted, signal peptide; Secreted; Cytokine Chromosomal Location of Human Ortholog: 19p13.11 Cellular Component: extracellular region; extracellular space Molecular Function:transforming growth factor beta receptor binding Biological Process: cell development; cell-cell signaling; regulation of apoptosis; regulation of MAPKKK cascade; signal transduction; transforming growth factor beta receptor signaling pathway |
| NCBI Summary: | The protein encoded by this gene belongs to the transforming growth factor-beta (TGF-beta) family. The protein is expressed in a broad range of cell types, acts as a pleiotropic cytokine and is involved in the stress reponse program of cells after cellular injury. Increased protein levels are associated with disease states such as tissue hypoxia, inflammation, acute injury and oxidative stress. [provided by RefSeq, Sep 2015] |
| UniProt Code: | Q99988 |
| NCBI GenInfo Identifier: | 313104195 |
| NCBI Gene ID: | 9518 |
| NCBI Accession: | Q99988.3 |
| UniProt Secondary Accession: | Q99988,O14629, P78360, Q9BWA0, Q9NRT0, |
| UniProt Related Accession: | Q99988 |
| Molecular Weight: | |
| NCBI Full Name: | Growth/differentiation factor 15 |
| NCBI Synonym Full Names: | growth differentiation factor 15 |
| NCBI Official Symbol: | GDF15 |
| NCBI Official Synonym Symbols: | PDF; MIC1; PLAB; MIC-1; NAG-1; PTGFB; GDF-15 |
| NCBI Protein Information: | growth/differentiation factor 15 |
| UniProt Protein Name: | Growth/differentiation factor 15 |
| UniProt Synonym Protein Names: | Macrophage inhibitory cytokine 1; MIC-1; NSAID-activated gene 1 protein; NAG-1; NSAID-regulated gene 1 protein; NRG-1; Placental TGF-beta; Placental bone morphogenetic protein; Prostate differentiation factor |
| Protein Family: | Growth/differentiation factor |
| UniProt Gene Name: | GDF15 |
| UniProt Entry Name: | GDF15_HUMAN |
 | Western blot analysis of extracts of various cell lines, using GDF15 antibody (CAB0185) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s. |
 | Immunohistochemistry of paraffin-embedded human placenta using GDF15 Rabbit pAb (CAB0185) at dilution of 1:100 (40x lens). |
 | Immunoprecipitation analysis of 200ug extracts of HT-1080 cells using 3ug GDF15 antibody (CAB0185). Western blot was performed from the immunoprecipitate using GDF15 antibody (CAB0185) at a dilition of 1:1000. |
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