Anti-GAD67/GAD1 Antibody (CAB1475)
- SKU:
- CAB1475
- Product type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- CPSQ1
- Synonyms:
- GAD
- Synonyms:
- SCP
Description
| 抗体名: | GAD67/GAD1 Rabbit mAb |
| 抗体コード: | CAB1475 |
| サイズ: | 20uL, 50uL, 100uL |
| 同義語: | CPSQ1, GAD, SCP |
| 申し込み: | WB |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | A synthesized peptide derived from human GAD67/GAD1 |
| 申し込み: | WB |
| 推奨される希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | 293T, U-251MG, Mouse lung, Rat lung |
| 免疫原: | A synthesized peptide derived from human GAD67/GAD1 |
| 精製方法: | Affinity purification |
| 保管所: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | Email for sequence |
| 遺伝子ID: | 2571 |
| Uniprot: | Q99259 |
| 計算された分子量: | 67kDa |
| 観察された分子量: | 70kDa |
| UniProt Protein Function: | GAD67: Catalyzes the production of GABA. Homodimer. Isoform 3 is expressed in pancreatic islets, testis, adrenal cortex, and perhaps other endocrine tissues, but not in brain. Belongs to the group II decarboxylase family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:EC 4.1.1.15; Other Amino Acids Metabolism - beta-alanine; Other Amino Acids Metabolism - taurine and hypotaurine; Carbohydrate Metabolism - butanoate; Amino Acid Metabolism - alanine, aspartate and glutamate; Mitochondrial; Lyase Chromosomal Location of Human Ortholog: 2q31 Cellular Component: plasma membrane; intracellular; vesicle membrane Molecular Function:protein binding; glutamate binding; glutamate decarboxylase activity; protein heterodimerization activity; protein N-terminus binding; pyridoxal phosphate binding Biological Process: response to drug; glutamate catabolic process; synaptic transmission; glutamate decarboxylation to succinate; neurotransmitter secretion; gamma-aminobutyric acid biosynthetic process; protein-pyridoxal-5-phosphate linkage; neurotransmitter biosynthetic process Disease: Cerebral Palsy, Spastic Quadriplegic, 1 |
| NCBI Summary: | This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantigen and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Deficiency in this enzyme has been shown to lead to pyridoxine dependency with seizures. Alternative splicing of this gene results in two products, the predominant 67-kD form and a less-frequent 25-kD form. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q99259 |
| NCBI GenInfo Identifier: | 1352213 |
| NCBI Gene ID: | 2571 |
| NCBI Accession: | Q99259.1 |
| UniProt Secondary Accession: | Q99259,Q49AK1, Q53TQ7, Q9BU91, Q9UHH4, |
| UniProt Related Accession: | Q99259 |
| Molecular Weight: | 66,897 Da |
| NCBI Full Name: | Glutamate decarboxylase 1 |
| NCBI Synonym Full Names: | glutamate decarboxylase 1 (brain, 67kDa) |
| NCBI Official Symbol: | GAD1 |
| NCBI Official Synonym Symbols: | GAD; SCP; CPSQ1 |
| NCBI Protein Information: | glutamate decarboxylase 1; GAD-67; 67 kDa glutamic acid decarboxylase; glutamate decarboxylase 67 kDa isoform |
| UniProt Protein Name: | Glutamate decarboxylase 1 |
| UniProt Synonym Protein Names: | 67 kDa glutamic acid decarboxylase; GAD-67; Glutamate decarboxylase 67 kDa isoform |
| Protein Family: | Glutamate decarboxylase |
| UniProt Gene Name: | GAD1 |
| UniProt Entry Name: | DCE1_HUMAN |