Anti-GABRA4 Antibody (CAB3870)
- SKU:
- CAB3870
- Product type:
- Antibody
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Signal Transduction
Frequently bought together:
Description
| 抗体名: | Anti-GABRA4 Antibody |
| 抗体コード: | CAB3870 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 36-258 of human GABRA4 (NP_000800.2). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Rat |
| ポジティブサンプル: | Rat kidney |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 36-258 of human GABRA4 (NP_000800.2). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | QNQK EEKL CTEN FTRI LDSL LDGY DNRL RPGF GGPV TEVK TDIY VTSF GPVS DVEM EYTM DVFF RQTW IDKR LKYD GPIE ILRL NNMM VTKV WTPD TFFR NGKK SVSH NMTA PNKL FRIM RNGT ILYT MRLT ISAE CPMR LVDF PMDG HACP LKFG SYAY PKSE MIYT WTKG PEKS VEVP KESS SLVQ YDLI GQTV SSET IKSI TGEY IVMT VYFH LRRK MGY |
| 遺伝子ID: | 2557 |
| Uniprot: | P48169 |
| セルラーロケーション: | Cell junction, Cell membrane, Multi-pass membrane protein, postsynaptic cell membrane, synapse |
| 計算された分子量: | 61kDa |
| 観察された分子量: | 72kDa |
| 同義語: | GABRA4 |
| バックグラウンド: | Gamma-aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified. This gene encodes subunit alpha-4, which is involved in the etiology of autism and eventually increases autism risk through interaction with another subunit, gamma-aminobutyric acid receptor beta-1 (GABRB1). Alternatively spliced transcript variants encoding different isoforms have been found in this gene. |
| UniProt Protein Function: | GABRA4: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRA4 sub-subfamily. |
| UniProt Protein Details: | Protein type:Transporter; Transporter, ion channel; Membrane protein, integral; Channel, chloride; Channel, ligand-gated; Membrane protein, multi-pass Chromosomal Location of Human Ortholog: 4p12 Cellular Component: cell junction; integral to plasma membrane; plasma membrane; postsynaptic membrane Molecular Function:benzodiazepine receptor activity; chloride channel activity; extracellular ligand-gated ion channel activity; GABA-A receptor activity Biological Process: central nervous system development; gamma-aminobutyric acid signaling pathway; synaptic transmission; transmembrane transport; transport |
| NCBI Summary: | Gamma-aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified. This gene encodes subunit alpha-4, which is involved in the etiology of autism and eventually increases autism risk through interaction with another subunit, gamma-aminobutyric acid receptor beta-1 (GABRB1). Alternatively spliced transcript variants encoding different isoforms have been found in this gene.[provided by RefSeq, Feb 2011] |
| UniProt Code: | P48169 |
| NCBI GenInfo Identifier: | 206729865 |
| NCBI Gene ID: | 2557 |
| NCBI Accession: | P48169.2 |
| UniProt Secondary Accession: | P48169,Q8IYR7, |
| UniProt Related Accession: | P48169 |
| Molecular Weight: | 61,623 Da |
| NCBI Full Name: | Gamma-aminobutyric acid receptor subunit alpha-4 |
| NCBI Synonym Full Names: | gamma-aminobutyric acid type A receptor alpha4 subunit |
| NCBI Official Symbol: | GABRA4 |
| NCBI Protein Information: | gamma-aminobutyric acid receptor subunit alpha-4 |
| UniProt Protein Name: | Gamma-aminobutyric acid receptor subunit alpha-4 |
| UniProt Synonym Protein Names: | GABA(A) receptor subunit alpha-4 |
| Protein Family: | Gamma-aminobutyric acid receptor |
| UniProt Gene Name: | GABRA4 |
| UniProt Entry Name: | GBRA4_HUMAN |
 | Western blot analysis of extracts of rat kidney, using GABRA4 antibody (CAB3870) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 45s. |
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