Anti-FXYD6 Antibody (CAB14339)
- SKU:
- CAB14339
- Product type:
- Antibody
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Frequently bought together:
Description
| 抗体名: | Anti-FXYD6 Antibody |
| 抗体コード: | CAB14339 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-95 of human FXYD6 (NP_071286.1). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Mouse, Rat |
| ポジティブサンプル: | Mouse brain, Mouse testis, Rat brain |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-95 of human FXYD6 (NP_071286.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | MELV LVFL CSLL APMV LASA AEKE KEMD PFHY DYQT LRIG GLVF AVVL FSVG ILLI LSRR CKCS FNQK PRAP GDEE AQVE NLIT ANAT EPQK AEN |
| 遺伝子ID: | 53826 |
| Uniprot: | Q9H0Q3 |
| セルラーロケーション: | Membrane, Single-pass type I membrane protein |
| 計算された分子量: | 10kDa/12kDa |
| 観察された分子量: | 20kDa |
| 同義語: | FXYD6 |
| バックグラウンド: | This gene encodes a member of the FXYD family of transmembrane proteins. This particular protein encodes phosphohippolin, which likely affects the activity of Na, K-ATPase. Multiple alternatively spliced transcript variants encoding the same protein have been described. Related pseudogenes have been identified on chromosomes 10 and X. Read-through transcripts have been observed between this locus and the downstream sodium/potassium-transporting ATPase subunit gamma (FXYD2, GeneID 486) locus. |
| UniProt Protein Function: | FXYD6: Genetic variations in FXYD6 are associated with susceptibility to schizophrenia type 2 (SCZD2). A complex, multifactorial psychotic disorder or group of disorders characterized by disturbances in the form and content of thought (e.g. delusions, hallucinations), in mood (e.g. inappropriate affect), in sense of self and relationship to the external world (e.g. loss of ego boundaries, withdrawal), and in behavior (e.g bizarre or apparently purposeless behavior). Although it affects emotions, it is distinguished from mood disorders in which such disturbances are primary. Similarly, there may be mild impairment of cognitive function, and it is distinguished from the dementias in which disturbed cognitive function is considered primary. Some patients manifest schizophrenic as well as bipolar disorder symptoms and are often given the diagnosis of schizoaffective disorder. Belongs to the FXYD family. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Channel, misc. Chromosomal Location of Human Ortholog: 11q23.3 Cellular Component: integral to membrane; plasma membrane Molecular Function:ion channel activity Biological Process: transmembrane transport |
| NCBI Summary: | This gene encodes a member of the FXYD family of transmembrane proteins. This particular protein encodes phosphohippolin, which likely affects the activity of Na,K-ATPase. Multiple alternatively spliced transcript variants encoding the same protein have been described. Related pseudogenes have been identified on chromosomes 10 and X. Read-through transcripts have been observed between this locus and the downstream sodium/potassium-transporting ATPase subunit gamma (FXYD2, GeneID 486) locus.[provided by RefSeq, Feb 2011] |
| UniProt Code: | Q9H0Q3 |
| NCBI GenInfo Identifier: | 20138342 |
| NCBI Gene ID: | 53826 |
| NCBI Accession: | Q9H0Q3.1 |
| UniProt Secondary Accession: | Q9H0Q3,Q6FIG9, Q6UW52, A8K0R4, J3QLD2, |
| UniProt Related Accession: | Q9H0Q3 |
| Molecular Weight: | 95 |
| NCBI Full Name: | FXYD domain-containing ion transport regulator 6 |
| NCBI Synonym Full Names: | FXYD domain containing ion transport regulator 6 |
| NCBI Official Symbol: | FXYD6 |
| NCBI Protein Information: | FXYD domain-containing ion transport regulator 6; phosphohippolin |
| UniProt Protein Name: | FXYD domain-containing ion transport regulator 6 |
| UniProt Synonym Protein Names: | Phosphohippolin |
| Protein Family: | FXYD domain-containing ion transport regulator |
| UniProt Gene Name: | FXYD6 |
| UniProt Entry Name: | FXYD6_HUMAN |
 | Western blot analysis of extracts of various cell lines, using FXYD6 antibody (CAB14339) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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