Anti-FUS Antibody (CAB5921)[KO Validated]
- SKU:
- CAB5921
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
抗体名: | Anti-FUS Antibody [KO Validated] |
抗体コード: | CAB5921 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB IHC IF IP |
反応性: | Human, Mouse, Rat |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 297-526 of human FUS (NP_004951.1). |
申し込み: | WB IHC IF IP |
推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:100 IF 1:50 - 1:100 IP 1:50 - 1:200 |
反応性: | Human, Mouse, Rat |
ポジティブサンプル: | U-937, Jurkat |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 297-526 of human FUS (NP_004951.1). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | TIES VADY FKQI GIIK TNKK TGQP MINL YTDR ETGK LKGE ATVS FDDP PSAK AAID WFDG KEFS GNPI KVSF ATRR ADFN RGGG NGRG GRGR GGPM GRGG YGGG GSGG GGRG GFPS GGGG GGGQ QRAG DWKC PNPT CENM NFSW RNEC NQCK APKP DGPG GGPG GSHM GGNY GDDR RGGR GGYD RGGY RGRG GDRG GFRG GRGG GDRG GFGP GKMD SRGE HRQD RRER PY |
遺伝子ID: | 2521 |
Uniprot: | P35637 |
セルラーロケーション: | Nucleus |
計算された分子量: | 53kDa |
観察された分子量: | 70kDa |
同義語: | FUS, ALS6, ETM4, FUS1, HNRNPP2, POMP75, TLS |
バックグラウンド: | This gene encodes a multifunctional protein component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complex. The hnRNP complex is involved in pre-mRNA splicing and the export of fully processed mRNA to the cytoplasm. This protein belongs to the FET family of RNA-binding proteins which have been implicated in cellular processes that include regulation of gene expression, maintenance of genomic integrity and mRNA/microRNA processing. Alternative splicing results in multiple transcript variants. Defects in this gene result in amyotrophic lateral sclerosis type 6. |
UniProt Protein Function: | hnRNP P2: Binds both single-stranded and double-stranded DNA and promotes ATP-independent annealing of complementary single- stranded DNAs and D-loop formation in superhelical double-stranded DNA. May play a role in maintenance of genomic integrity. Component of nuclear riboprotein complexes. Interacts with ILF3, TDRD3 and SF1. Interacts through its C-terminus with SFRS13A. Interacts with OTUB1 and SARNP. Ubiquitous. Belongs to the RRM TET family. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Oncoprotein; RNA-binding; Nuclear receptor co-regulator; DNA-binding; RNA splicing Chromosomal Location of Human Ortholog: 16p11.2 Cellular Component: nucleoplasm; cytoplasm; nucleus Molecular Function:identical protein binding; protein binding; DNA binding; zinc ion binding; RNA binding; nucleotide binding Biological Process: nuclear mRNA splicing, via spliceosome; RNA splicing; gene expression Disease: Amyotrophic Lateral Sclerosis 6, With Or Without Frontotemporal Dementia; Tremor, Hereditary Essential, 4 |
NCBI Summary: | This gene encodes a multifunctional protein component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complex. The hnRNP complex is involved in pre-mRNA splicing and the export of fully processed mRNA to the cytoplasm. This protein belongs to the FET family of RNA-binding proteins which have been implicated in cellular processes that include regulation of gene expression, maintenance of genomic integrity and mRNA/microRNA processing. Alternative splicing results in multiple transcript variants. Defects in this gene result in amyotrophic lateral sclerosis type 6. [provided by RefSeq, Sep 2009] |
UniProt Code: | P35637 |
NCBI GenInfo Identifier: | 544357 |
NCBI Gene ID: | 2521 |
NCBI Accession: | P35637.1 |
UniProt Secondary Accession: | P35637,Q9H4A8, |
UniProt Related Accession: | P35637 |
Molecular Weight: | Calculated MW: 53kDaObserved MW: 70kDa |
NCBI Full Name: | RNA-binding protein FUS |
NCBI Synonym Full Names: | FUS RNA binding protein |
NCBI Official Symbol: | FUS |
NCBI Official Synonym Symbols: | TLS; ALS6; ETM4; FUS1; POMP75; HNRNPP2 |
NCBI Protein Information: | RNA-binding protein FUS; oncogene FUS; oncogene TLS; fus-like protein; fused in sarcoma; 75 kDa DNA-pairing protein; fusion gene in myxoid liposarcoma; translocated in liposarcoma protein; heterogeneous nuclear ribonucleoprotein P2 |
UniProt Protein Name: | RNA-binding protein FUS |
UniProt Synonym Protein Names: | 75 kDa DNA-pairing protein; Oncogene FUS; Oncogene TLS; POMp75; Translocated in liposarcoma protein |
Protein Family: | Fusion protein |
UniProt Gene Name: | FUS |
UniProt Entry Name: | FUS_HUMAN |
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