Anti-FST Antibody (CAB2936)
- SKU:
- CAB2936
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| 抗体名: | Anti-FST Antibody |
| 抗体コード: | CAB2936 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | A synthetic peptide of human FST |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | HepG2 |
| 免疫原: | A synthetic peptide of human FST |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | Email for sequence |
| 遺伝子ID: | 10468 |
| Uniprot: | P19883 |
| セルラーロケーション: | Secreted |
| 計算された分子量: | 34kDa/38kDa |
| 観察された分子量: | 38kDa |
| 同義語: | FST, FS |
| バックグラウンド: | Follistatin is a single-chain gonadal protein that specifically inhibits follicle-stimulating hormone release. The single FST gene encodes two isoforms, FST317 and FST344 containing 317 and 344 amino acids respectively, resulting from alternative splicing of the precursor mRNA. In a study in which 37 candidate genes were tested for linkage and association with polycystic ovary syndrome (PCOS) or hyperandrogenemia in 150 families, evidence was found for linkage between PCOS and follistatin. |
| UniProt Protein Function: | FST: Binds directly to activin and functions as an activin antagonist. Specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone (FSH). 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 5q11.2 Cellular Component: cytoplasm; extracellular region; nucleus Molecular Function:heparan sulfate proteoglycan binding; signal transducer activity; protein binding; activin binding Biological Process: BMP signaling pathway; positive regulation of hair follicle development; negative regulation of activin receptor signaling pathway; negative regulation of cell differentiation; hair follicle morphogenesis; gamete generation; hemopoietic progenitor cell differentiation; keratinocyte proliferation; negative regulation of transcription from RNA polymerase II promoter; pattern specification process; skeletal development; female gonad development; odontogenesis of dentine-containing teeth Disease: Polycystic Ovary Syndrome 1 |
| NCBI Summary: | Follistatin is a single-chain gonadal protein that specifically inhibits follicle-stimulating hormone release. The single FST gene encodes two isoforms, FST317 and FST344 containing 317 and 344 amino acids respectively, resulting from alternative splicing of the precursor mRNA. In a study in which 37 candidate genes were tested for linkage and association with polycystic ovary syndrome (PCOS) or hyperandrogenemia in 150 families, evidence was found for linkage between PCOS and follistatin. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P19883 |
| NCBI GenInfo Identifier: | 23831079 |
| NCBI Gene ID: | 10468 |
| NCBI Accession: | P19883.2 |
| UniProt Secondary Accession: | P19883,Q9BTH0, B5BU94, |
| UniProt Related Accession: | P19883 |
| Molecular Weight: | 34,803 Da |
| NCBI Full Name: | Follistatin |
| NCBI Synonym Full Names: | follistatin |
| NCBI Official Symbol: | FST |
| NCBI Official Synonym Symbols: | FS |
| NCBI Protein Information: | follistatin; activin-binding protein; follistatin isoform FST317 |
| UniProt Protein Name: | Follistatin |
| UniProt Synonym Protein Names: | Activin-binding protein |
| Protein Family: | Follistatin |
| UniProt Gene Name: | FST |
| UniProt Entry Name: | FST_HUMAN |
 | Western blot analysis of extracts of HepG2 cells, using FST antibody (CAB2936). Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. |