Anti-FOXRED1 Antibody (CAB10369)
- SKU:
- CAB10369
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-FOXRED1 Antibody |
| 抗体コード: | CAB10369 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 307-486 of human FOXRED1 (NP_060017.1). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | HeLa, HepG2, A-549, K-562, Mouse kidney, Mouse lung, Rat kidney, Rat lung |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 307-486 of human FOXRED1 (NP_060017.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | GPPG TLQG TKLP VEPR KRYV YVWH CPQG PGLE TPLV ADTS GAYF RREG LGSN YLGG RSPT EQEE PDPA NLEV DHDF FQDK VWPH LALR VPAF ETLK VQSA WAGY YDYN TFDQ NGVV GPHP LVVN MYFA TGFS GHGL QQAP GIGR AVAE MVLK GRFQ TIDL SPFL FTRF YLGE KIQE NNII |
| 遺伝子ID: | 55572 |
| Uniprot: | Q96CU9 |
| セルラーロケーション: | Mitochondrion inner membrane, Single-pass membrane protein |
| 計算された分子量: | 30kDa/52kDa/53kDa |
| 観察された分子量: | 58kDa |
| 同義語: | FOXRED1, FP634, H17 |
| バックグラウンド: | This gene encodes a protein that contains a FAD-dependent oxidoreductase domain. The encoded protein is localized to the mitochondria and may function as a chaperone protein required for the function of mitochondrial complex I. Mutations in this gene are associated with mitochondrial complex I deficiency. Alternatively spliced transcript variants have been observed for this gene. |
| UniProt Protein Function: | FOXRED1: Defects in FOXRED1 are a cause of mitochondrial complex I deficiency (MT-C1D). A disorder of the mitochondrial respiratory chain that causes a wide range of clinical manifestations from lethal neonatal disease to adult-onset neurodegenerative disorders. Phenotypes include macrocephaly with progressive leukodystrophy, non-specific encephalopathy, cardiomyopathy, myopathy, liver disease, Leigh syndrome, Leber hereditary optic neuropathy, and some forms of Parkinson disease. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Mitochondrial Chromosomal Location of Human Ortholog: 11q24.2 Cellular Component: mitochondrial inner membrane; mitochondrial respiratory chain complex I; mitochondrion Biological Process: mitochondrial respiratory chain complex I assembly Disease: Leigh Syndrome; Mitochondrial Complex I Deficiency |
| NCBI Summary: | This gene encodes a protein that contains a FAD-dependent oxidoreductase domain. The encoded protein is localized to the mitochondria and may function as a chaperone protein required for the function of mitochondrial complex I. Mutations in this gene are associated with mitochondrial complex I deficiency. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Dec 2010] |
| UniProt Code: | Q96CU9 |
| NCBI GenInfo Identifier: | 124007188 |
| NCBI Gene ID: | 55572 |
| NCBI Accession: | Q96CU9.2 |
| UniProt Secondary Accession: | Q96CU9,Q71MG0, Q9BU39, Q9UKY9, B3KN84, B4DHU2, |
| UniProt Related Accession: | Q96CU9 |
| Molecular Weight: | 52,104 Da |
| NCBI Full Name: | FAD-dependent oxidoreductase domain-containing protein 1 |
| NCBI Synonym Full Names: | FAD dependent oxidoreductase domain containing 1 |
| NCBI Official Symbol: | FOXRED1 |
| NCBI Official Synonym Symbols: | H17; FP634 |
| NCBI Protein Information: | FAD-dependent oxidoreductase domain-containing protein 1 |
| UniProt Protein Name: | FAD-dependent oxidoreductase domain-containing protein 1 |
| Protein Family: | FAD-dependent oxidoreductase domain-containing protein |
| UniProt Gene Name: | FOXRED1 |
| UniProt Entry Name: | FXRD1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using FOXRED1 antibody (CAB10369) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 60s. |
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