Anti-FOSB Antibody (CAB14696)
- SKU:
- CAB14696
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
抗体名: | Anti-FOSB Antibody |
抗体コード: | CAB14696 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB |
反応性: | Human, Mouse, Rat |
宿主種: | Rabbit |
免疫原: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human FOSB (NP_006723.2). |
申し込み: | WB |
推奨希釈: | WB 1:500 - 1:2000 |
反応性: | Human, Mouse, Rat |
ポジティブサンプル: | U-87MG, SKOV3, HeLa, Mouse brain, Rat brain |
免疫原: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human FOSB (NP_006723.2). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | MFQA FPGD YDSG SRCS SSPS AESQ YLSS VDSF GSPP TAAA SQEC AGLG EMPG SFVP TVTA ITTS QDLQ WLVQ PTLI SSMA QSQG QPLA SQPP VVDP YDMP |
遺伝子ID: | 2354 |
Uniprot: | P53539 |
セルラーロケーション: | Nucleus |
計算された分子量: | 15kDa/20kDa/26kDa/27kDa/30kDa/31kDa/35kDa |
観察された分子量: | 37kDa |
同義語: | FOSB, AP-1, G0S3, GOS3, GOSB |
バックグラウンド: | The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
UniProt Protein Function: | FosB: FosB interacts with Jun proteins enhancing their DNA binding activity. Heterodimer. Belongs to the bZIP family. Fos subfamily. |
UniProt Protein Details: | Protein type:Transcription factor; DNA-binding Chromosomal Location of Human Ortholog: 19q13.32 Cellular Component: nucleus Molecular Function:DNA binding; sequence-specific DNA binding; double-stranded DNA binding; transcription factor activity; transcription factor binding Biological Process: transcription from RNA polymerase II promoter; response to drug; response to cAMP; response to mechanical stimulus; response to morphine; negative regulation of transcription from RNA polymerase II promoter; female pregnancy; response to progesterone stimulus; response to corticosterone stimulus; cellular response to hormone stimulus |
NCBI Summary: | The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
UniProt Code: | P53539 |
NCBI GenInfo Identifier: | 1706888 |
NCBI Gene ID: | 2354 |
NCBI Accession: | P53539.1 |
UniProt Secondary Accession: | P53539,A8K9K5, A8VJE1, A8VJE6, A8VJF0, A8VJF3, A8VJF7 A8VJG1, A8VJG5, A8VJG9, E7EPR6, E9PHJ3, |
UniProt Related Accession: | P53539 |
Molecular Weight: | 30,978 Da |
NCBI Full Name: | Protein fosB |
NCBI Synonym Full Names: | FBJ murine osteosarcoma viral oncogene homolog B |
NCBI Official Symbol: | FOSB |
NCBI Official Synonym Symbols: | AP-1; G0S3; GOS3; GOSB |
NCBI Protein Information: | protein fosB; activator protein 1; G0/G1 switch regulatory protein 3 |
UniProt Protein Name: | Protein fosB |
UniProt Synonym Protein Names: | G0/G1 switch regulatory protein 3 |
Protein Family: | Protein |
UniProt Gene Name: | FOSB |
UniProt Entry Name: | FOSB_HUMAN |
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