Anti-FNBP1 Antibody (CAB10289)
- SKU:
- CAB10289
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-FNBP1 Antibody |
| 抗体コード: | CAB10289 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-210 of human FNBP1 (NP_055848.1). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:1000 - 1:2000 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | SGC-7901, LO2, HeLa, U-87MG, BT-474 |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-210 of human FNBP1 (NP_055848.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | MSWG TELW DQFD NLEK HTQW GIDI LEKY IKFV KERT EIEL SYAK QLRN LSKK YQPK KNSK EEEE YKYT SCKA FISN LNEM NDYA GQHE VISE NMAS QIIV DLAR YVQE LKQE RKSN FHDG RKAQ QHIE TCWK QLES SKRR FERD CKEA DRAQ QYFE KMDA DINV TKAD VEKA RQQA QIRH QMAE DSKA DYSS ILQK FNHE QHEY YHTH IP |
| 遺伝子ID: | 23048 |
| Uniprot: | Q96RU3 |
| セルラーロケーション: | Cell membrane, Cytoplasm, Cytoplasmic side, Cytoplasmic vesicle, Lysosome, Membrane, Peripheral membrane protein, cell cortex, clathrin-coated pit, cytoskeleton |
| 計算された分子量: | 64kDa/68kDa/70kDa/71kDa |
| 観察された分子量: | 71kDa |
| 同義語: | FNBP1, FBP17 |
| バックグラウンド: | The protein encoded by this gene is a member of the formin-binding-protein family. The protein contains an N-terminal Fer/Cdc42-interacting protein 4 (CIP4) homology (FCH) domain followed by a coiled-coil domain, a proline-rich motif, a second coiled-coil domain, a Rho family protein-binding domain (RBD), and a C-terminal SH3 domain. This protein binds sorting nexin 2 (SNX2), tankyrase (TNKS), and dynamin; an interaction between this protein and formin has not been demonstrated yet in human. |
| UniProt Protein Function: | FNBP1: May act as a link between RND2 signaling and regulation of the actin cytoskeleton. Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during the late stage of clathrin-mediated endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also enhances actin polymerization via the recruitment of WASL/N-WASP, which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. May be required for the lysosomal retention of FASLG/FASL. A chromosomal aberration involving FNBP1 is found in acute leukemias. Translocation t(9;11)(q34;q23) with MLL. The relatively low incidence of the MLL-FNBP1 fusion protein in acute leukemia may reflect the marginal capacity of this fusion protein to induce cellular transformation. Belongs to the FNBP1 family. 4 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Actin-binding; Vesicle Chromosomal Location of Human Ortholog: 9q34.11 Cellular Component: cytosol Molecular Function:identical protein binding; protein binding |
| NCBI Summary: | The protein encoded by this gene is a member of the formin-binding-protein family. The protein contains an N-terminal Fer/Cdc42-interacting protein 4 (CIP4) homology (FCH) domain followed by a coiled-coil domain, a proline-rich motif, a second coiled-coil domain, a Rho family protein-binding domain (RBD), and a C-terminal SH3 domain. This protein binds sorting nexin 2 (SNX2), tankyrase (TNKS), and dynamin; an interaction between this protein and formin has not been demonstrated yet in human. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q96RU3 |
| NCBI GenInfo Identifier: | 118572321 |
| NCBI Gene ID: | 23048 |
| NCBI Accession: | Q96RU3.2 |
| UniProt Secondary Accession: | Q96RU3,O60301, Q3MIN8, Q5TC87, Q5TC88, Q6P658, Q7LGG2 Q9H8H8, Q9NWD1, B7ZL12, E9PGQ4, |
| UniProt Related Accession: | Q96RU3 |
| Molecular Weight: | 71kDa |
| NCBI Full Name: | Formin-binding protein 1 |
| NCBI Synonym Full Names: | formin binding protein 1 |
| NCBI Official Symbol: | FNBP1 |
| NCBI Official Synonym Symbols: | FBP17 |
| NCBI Protein Information: | formin-binding protein 1 |
| UniProt Protein Name: | Formin-binding protein 1 |
| UniProt Synonym Protein Names: | Formin-binding protein 17; hFBP17 |
| Protein Family: | Formin-binding protein |
| UniProt Gene Name: | FNBP1 |
 | Western blot analysis of extracts of various cell lines, using FNBP1 antibody (CAB10289) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 20s. |
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