Anti-FMO5 Antibody (CAB7673)
- SKU:
- CAB7673
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-FMO5 Antibody |
| 抗体コード: | CAB7673 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IF |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-285 of human FMO5 (NP_001138302.1). |
| 申し込み: | WB IF |
| 推奨希釈: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | Mouse liver, Rat liver |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-285 of human FMO5 (NP_001138302.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | MTKK RIAV IGGG VSGL SSIK CCVE EGLE PVCF ERTD DIGG LWRF QENP EEGR ASIY KSVI INTS KEMM CFSD YPIP DHYP NFMH NAQV LEYF RMYA KEFD LLKY IRFK TTVC SVKK QPDF ATSG QWEV VTES EGKK EMNV FDGV MVCT GHHT NAHL PLES FPGI EKFK GQYF HSRD YKNP EGFT GKRV IIIG IGNS GGDL AVEI SQTA KQVF LSTR RGAW ILNR VGDY GYPA DVLF SSRL THFI WKIC GQSL ANKY LEKK INQR FDHE MFGL KPKH RSKD IALT E |
| 遺伝子ID: | 2330 |
| Uniprot: | P49326 |
| セルラーロケーション: | Endoplasmic reticulum membrane, Microsome membrane |
| 計算された分子量: | 32kDa/52kDa/60kDa |
| 観察された分子量: | 60kDa |
| 同義語: | FMO5 |
| バックグラウンド: | Metabolic N-oxidation of the diet-derived amino-trimethylamine (TMA) is mediated by flavin-containing monooxygenase and is subject to an inherited FMO3 polymorphism in man resulting in a small subpopulation with reduced TMA N-oxidation capacity resulting in fish odor syndrome Trimethylaminuria. Three forms of the enzyme, FMO1 found in fetal liver, FMO2 found in adult liver, and FMO3 are encoded by genes clustered in the 1q23-q25 region. Flavin-containing monooxygenases are NADPH-dependent flavoenzymes that catalyzes the oxidation of soft nucleophilic heteroatom centers in drugs, pesticides, and xenobiotics. Alternative splicing results in multiple transcript variants. |
| UniProt Protein Function: | FMO5: In contrast with other forms of FMO it does not seem to be a drug-metabolizing enzyme. Belongs to the FMO family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:EC 1.14.13.8; Oxidoreductase; Xenobiotic Metabolism - drug metabolism - cytochrome P450 Chromosomal Location of Human Ortholog: 1q21.1 Cellular Component: endoplasmic reticulum membrane; integral to membrane Molecular Function:FAD binding; NADP binding; flavin-containing monooxygenase activity |
| NCBI Summary: | Metabolic N-oxidation of the diet-derived amino-trimethylamine (TMA) is mediated by flavin-containing monooxygenase and is subject to an inherited FMO3 polymorphism in man resulting in a small subpopulation with reduced TMA N-oxidation capacity resulting in fish odor syndrome Trimethylaminuria. Three forms of the enzyme, FMO1 found in fetal liver, FMO2 found in adult liver, and FMO3 are encoded by genes clustered in the 1q23-q25 region. Flavin-containing monooxygenases are NADPH-dependent flavoenzymes that catalyzes the oxidation of soft nucleophilic heteroatom centers in drugs, pesticides, and xenobiotics. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2009] |
| UniProt Code: | P49326 |
| NCBI GenInfo Identifier: | 1346021 |
| NCBI Gene ID: | 2330 |
| NCBI Accession: | P49326.2 |
| UniProt Secondary Accession: | P49326,P97872, Q8K4C0, |
| UniProt Related Accession: | P49326 |
| Molecular Weight: | 533 |
| NCBI Full Name: | Dimethylaniline monooxygenase |
| NCBI Synonym Full Names: | flavin containing monooxygenase 5 |
| NCBI Official Symbol: | FMO5 |
| NCBI Protein Information: | dimethylaniline monooxygenase [N-oxide-forming] 5; dimethylaniline monooxygenase [N-oxide-forming] 5; FMO 5; dimethylaniline oxidase 5; hepatic flavin-containing monooxygenase 5 |
| UniProt Protein Name: | Dimethylaniline monooxygenase [N-oxide-forming] 5 |
| UniProt Synonym Protein Names: | Dimethylaniline oxidase 5; Hepatic flavin-containing monooxygenase 5; FMO 5 |
| Protein Family: | Dimethylaniline monooxygenase |
| UniProt Gene Name: | FMO5 |
| UniProt Entry Name: | FMO5_HUMAN |
 | Western blot analysis of extracts of various cell lines, using FMO5 antibody (CAB7673) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s. |
 | Immunofluorescence analysis of U2OS cells using FMO5 antibody (CAB7673) at dilution of 1:100. Blue: DAPI for nuclear staining. |
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