Anti-FMO2 Antibody (CAB13981)
- SKU:
- CAB13981
- Product type:
- Antibody
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-FMO2 Antibody |
| 抗体コード: | CAB13981 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 210-470 of human FMO2 (NP_001451.2). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Mouse, Rat |
| ポジティブサンプル: |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 210-470 of human FMO2 (NP_001451.2). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | VFIS TRHG TWVM SRIS EDGY PWDS VFHT RFRS MLRN VLPR TAVK WMIE QQMN RWFN HENY GLEP QNKY IMKE PVLN DDVP SRLL CGAI KVKS TVKE LTET SAIF EDGT VEEN IDVI IFAT GYSF SFPF LEDS LVKV ENNM VSLY KYIF PAHL DKST LACI GLIQ PLGS IFPT AELQ ARWV TRVF KGLC SLPS ERTM MMDI IKRN EKRI DLFG ESQS QTLQ TNYV DYLD ELAL EIGA KPDF CSLL FKDP KLAV RLYF GPCN S |
| 遺伝子ID: | 2327 |
| Uniprot: | Q99518 |
| セルラーロケーション: | Endoplasmic reticulum membrane, Microsome membrane |
| 計算された分子量: | 53kDa |
| 観察された分子量: | Refer to figures |
| 同義語: | FMO2, FMO1B1 |
| バックグラウンド: | This gene encodes a flavin-containing monooxygenase family member. It is an NADPH-dependent enzyme that catalyzes the N-oxidation of some primary alkylamines through an N-hydroxylamine intermediate. However, some human populations contain an allele (FMO2*2A) with a premature stop codon, resulting in a protein that is C-terminally-truncated, has no catalytic activity, and is likely degraded rapidly. This gene is found in a cluster with other related family members on chromosome 1. Alternative splicing results in multiple transcript variants. |
| UniProt Protein Function: | FMO2: Catalyzes the N-oxidation of certain primary alkylamines to their oximes via an N-hydroxylamine intermediate. Inactive toward certain tertiary amines, such as imipramine or chloropromazine. Can catalyze the S-oxidation of methimazole. The truncated form is catalytically inactive. Belongs to the FMO family. |
| UniProt Protein Details: | Protein type:EC 1.14.13.8; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Oxidoreductase Chromosomal Location of Human Ortholog: 1q24.3 Cellular Component: endoplasmic reticulum membrane; membrane; integral to membrane Molecular Function:FAD binding; NADP binding; monooxygenase activity; flavin-containing monooxygenase activity Biological Process: organic acid metabolic process; toxin metabolic process; xenobiotic metabolic process; drug metabolic process; NADP metabolic process |
| NCBI Summary: | This gene encodes a flavin-containing monooxygenase family member. It is an NADPH-dependent enzyme that catalyzes the N-oxidation of some primary alkylamines through an N-hydroxylamine intermediate. However, some human populations contain an allele (FMO2*2A) with a premature stop codon, resulting in a protein that is C-terminally-truncated, has no catalytic activity, and is likely degraded rapidly. This gene is found in a cluster with other related family members on chromosome 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2014] |
| UniProt Code: | Q99518 |
| NCBI GenInfo Identifier: | 327478599 |
| NCBI Gene ID: | 2327 |
| NCBI Accession: | Q99518.4 |
| UniProt Secondary Accession: | Q99518,Q5EBX4, Q86U73, Q9BRX1, |
| UniProt Related Accession: | Q99518 |
| Molecular Weight: | 471 |
| NCBI Full Name: | Dimethylaniline monooxygenase |
| NCBI Synonym Full Names: | flavin containing monooxygenase 2 (non-functional) |
| NCBI Official Symbol: | FMO2 |
| NCBI Official Synonym Symbols: | FMO1B1 |
| NCBI Protein Information: | dimethylaniline monooxygenase [N-oxide-forming] 2; dimethylaniline monooxygenase [N-oxide-forming] 2; FMO, pulmonary; dimethylaniline oxidase 2; pulmonary flavin-containing monooxygenase 2 |
| UniProt Protein Name: | Dimethylaniline monooxygenase [N-oxide-forming] 2 |
| UniProt Synonym Protein Names: | Dimethylaniline oxidase 2; FMO 1B1; Pulmonary flavin-containing monooxygenase 2; FMO 2 |
| Protein Family: | Dimethylaniline monooxygenase |
| UniProt Gene Name: | FMO2 |
| UniProt Entry Name: | FMO2_HUMAN |
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