Anti-FMO1 Antibody (CAB6908)
- SKU:
- CAB6908
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-FMO1 Antibody |
| 抗体コード: | CAB6908 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IF |
| 反応性: | Human, Mouse |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 363-532 of human FMO1 (NP_002012.1). |
| 申し込み: | WB IF |
| 推奨希釈: | WB 1:500 - 1:2000 IF 1:50 - 1:100 |
| 反応性: | Human, Mouse |
| ポジティブサンプル: | Mouse liver |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 363-532 of human FMO1 (NP_002012.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | KPTL AIIG LIKP LGSM IPTG ETQA RWAV RVLK GVNK LPPP SVMI EEIN ARKE NKPS WFGL CYCK ALQS DYIT YIDE LLTY INAK PNLF SMLL TDPH LALT VFFG PCSP YQFR LTGP GKWE GARN AIMT QWDR TFKV IKAR VVQE SPSP FESF LKVF SFLA LLVA IFLI FL |
| 遺伝子ID: | 2326 |
| Uniprot: | Q01740 |
| セルラーロケーション: | Endoplasmic reticulum membrane, Microsome membrane |
| 計算された分子量: | 52kDa/60kDa |
| 観察された分子量: | 60kDa |
| 同義語: | FMO1 |
| バックグラウンド: | Metabolic N-oxidation of the diet-derived amino-trimethylamine (TMA) is mediated by flavin-containing monooxygenase and is subject to an inherited FMO3 polymorphism in man resulting in a small subpopulation with reduced TMA N-oxidation capacity resulting in fish odor syndrome Trimethylaminuria. Three forms of the enzyme, FMO1 found in fetal liver, FMO2 found in adult liver, and FMO3 are encoded by genes clustered in the 1q23-q25 region. Flavin-containing monooxygenases are NADPH-dependent flavoenzymes that catalyzes the oxidation of soft nucleophilic heteroatom centers in drugs, pesticides, and xenobiotics. Several transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | FMO1: This protein is involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides. Form I catalyzes the N-oxygenation of secondary and tertiary amines. Belongs to the FMO family. |
| UniProt Protein Details: | Protein type:EC 1.14.13.8; Oxidoreductase; Xenobiotic Metabolism - drug metabolism - cytochrome P450 Chromosomal Location of Human Ortholog: 1q24.3 Cellular Component: endoplasmic reticulum membrane; endoplasmic reticulum lumen; integral to membrane Molecular Function:FAD binding; NADP binding; monooxygenase activity; flavin-containing monooxygenase activity Biological Process: organic acid metabolic process; toxin metabolic process; xenobiotic metabolic process; response to lipopolysaccharide; response to osmotic stress; drug metabolic process |
| NCBI Summary: | Metabolic N-oxidation of the diet-derived amino-trimethylamine (TMA) is mediated by flavin-containing monooxygenase and is subject to an inherited FMO3 polymorphism in man resulting in a small subpopulation with reduced TMA N-oxidation capacity resulting in fish odor syndrome Trimethylaminuria. Three forms of the enzyme, FMO1 found in fetal liver, FMO2 found in adult liver, and FMO3 are encoded by genes clustered in the 1q23-q25 region. Flavin-containing monooxygenases are NADPH-dependent flavoenzymes that catalyzes the oxidation of soft nucleophilic heteroatom centers in drugs, pesticides, and xenobiotics. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013] |
| UniProt Code: | Q01740 |
| NCBI GenInfo Identifier: | 399505 |
| NCBI Gene ID: | 2326 |
| NCBI Accession: | Q01740.3 |
| UniProt Secondary Accession: | Q01740,Q5QPT2, Q9UJC2, A8K248, B7Z3P4, |
| UniProt Related Accession: | Q01740 |
| Molecular Weight: | 532 |
| NCBI Full Name: | Dimethylaniline monooxygenase |
| NCBI Synonym Full Names: | flavin containing monooxygenase 1 |
| NCBI Official Symbol: | FMO1 |
| NCBI Protein Information: | dimethylaniline monooxygenase [N-oxide-forming] 1; dimethylaniline monooxygenase [N-oxide-forming] 1; FMO 1; dimethylaniline oxidase 1; Flavin-containing monooxygenase 1 (fetal liver); fetal hepatic flavin-containing monooxygenase 1 |
| UniProt Protein Name: | Dimethylaniline monooxygenase [N-oxide-forming] 1 |
| UniProt Synonym Protein Names: | Dimethylaniline oxidase 1; Fetal hepatic flavin-containing monooxygenase 1; FMO 1 |
| Protein Family: | Thiol-specific monooxygenase |
| UniProt Gene Name: | FMO1 |
| UniProt Entry Name: | FMO1_HUMAN |
 | Western blot analysis of extracts of mouse liver, using FMO1 antibody (CAB6908) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 150s. |
 | Immunofluorescence analysis of HeLa cells using FMO1 antibody (CAB6908). Blue: DAPI for nuclear staining. |
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