Anti-FKBP8 Antibody (CAB1268)

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SKU:
CAB1268
Product type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Death
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Description

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抗体名:Anti-FKBP8 Antibody
抗体コード:CAB1268
抗体サイズ:100µL
申し込み:WB IF IP
反応性:Human, Mouse
宿主種:Rabbit
免疫原:Recombinant protein of human FKBP8
申し込み:WB IF IP
推奨希釈:WB 1:500 - 1:2000 IF 1:20 - 1:100 IP 1:20 - 1:50
反応性:Human, Mouse
ポジティブサンプル:Jurkat
免疫原:Recombinant protein of human FKBP8
精製方法:Affinity purification
ストレージバッファ:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
アイソタイプ:IgG
順序:Email for sequence
遺伝子ID:23770
Uniprot:Q14318
セルラーロケーション:Cytoplasmic side, Mitochondrion membrane, Single-pass membrane protein
計算された分子量:27kDa/44kDa
観察された分子量:45kDa
同義語:FKBP8, FKBP38, FKBPr38
バックグラウンド:The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. Unlike the other members of the family, this encoded protein does not seem to have PPIase/rotamase activity. It may have a role in neurons associated with memory function.
UniProt Protein Function:FKBP8: Constitutively inactive PPiase, which becomes active when bound to calmodulin and calcium. Seems to act as a chaperone for BCL2, targets it to the mitochondria and modulates its phosphorylation state. The BCL2/FKBP8/calmodulin/calcium complex probably interferes with the binding of BCL2 to its targets. The active form of FKBP8 may therefore play a role in the regulation of apoptosis. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Chaperone; Isomerase; Mitochondrial; EC 5.2.1.8; Membrane protein, integral

Chromosomal Location of Human Ortholog: 19p12

Cellular Component: endoplasmic reticulum membrane; membrane; mitochondrial membrane; integral to endoplasmic reticulum membrane

Molecular Function:identical protein binding; protein binding; FK506 binding; peptidyl-prolyl cis-trans isomerase activity; metal ion binding

Biological Process: smoothened signaling pathway; camera-type eye development; protein peptidyl-prolyl isomerization; viral reproduction; apoptosis; regulation of gene expression; multicellular organism growth; cell fate specification; positive regulation of BMP signaling pathway; dorsoventral neural tube patterning; negative regulation of apoptosis

NCBI Summary:The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. Unlike the other members of the family, this encoded protein does not seem to have PPIase/rotamase activity. It may have a role in neurons associated with memory function. [provided by RefSeq, Jul 2008]
UniProt Code:Q14318
NCBI GenInfo Identifier:193806337
NCBI Gene ID:23770
NCBI Accession:Q14318.2
UniProt Related Accession:Q14318
Molecular Weight:55kDa
NCBI Full Name:Peptidyl-prolyl cis-trans isomerase FKBP8
NCBI Synonym Full Names:FKBP prolyl isomerase 8
NCBI Official Symbol:FKBP8  
NCBI Official Synonym Symbols:FKBP38; FKBPr38  
NCBI Protein Information:peptidyl-prolyl cis-trans isomerase FKBP8
UniProt Protein Name:Peptidyl-prolyl cis-trans isomerase FKBP8
UniProt Synonym Protein Names:38 kDa FK506-binding protein; 38 kDa FKBP; FKBP-38; hFKBP38; FK506-binding protein 8; FKBP-8; FKBPR38; Rotamase
Protein Family:Peptidyl-prolyl cis-trans isomerase
UniProt Gene Name:FKBP8  
UniProt Entry Name:FKBP8_HUMAN
Anti-FKBP8 Antibody (CAB1268)Western blot analysis of extracts of Jurkat cells, using FKBP8 antibody (CAB1268). Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST.
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