Anti-FGFR1OP Antibody (CAB17627)
- SKU:
- CAB17627
- Product type:
- Antibody
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
Frequently bought together:
Description
| 抗体名: | Anti-FGFR1OP Antibody |
| 抗体コード: | CAB17627 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-70 of human FGFR1OP (NP_919410.1). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Mouse, Rat |
| ポジティブサンプル: | Mouse kidney, Mouse brain |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-70 of human FGFR1OP (NP_919410.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | MAAT AAAV VAEE DTEL RDLL VQTL ENSG VLNR IKAE LRAA VFLA LEEQ EKVE NKTP LVNE SLKK FLNT KD |
| 遺伝子ID: | 11116 |
| Uniprot: | O95684 |
| セルラーロケーション: | |
| 計算された分子量: | 16kDa/40kDa/43kDa |
| 観察された分子量: | 43kDa |
 | Western blot - FGFR1OP Polyclonal Antibody (CAB17627) |
| 同義語: | FGFR1OP, FOP |
| バックグラウンド: | This gene encodes a largely hydrophilic centrosomal protein that is required for anchoring microtubules to subcellular structures. A t(6;8)(q27;p11) chromosomal translocation, fusing this gene and the fibroblast growth factor receptor 1 (FGFR1) gene, has been found in cases of myeloproliferative disorder. The resulting chimeric protein contains the N-terminal leucine-rich region of this encoded protein fused to the catalytic domain of FGFR1. Alterations in this gene may also be associated with Crohn's disease, Graves' disease, and vitiligo. Alternatively spliced transcript variants that encode different proteins have been identified. [provided by RefSeq, Jul 2013] |
| UniProt Protein Function: | FOP: Required for anchoring microtubules to the centrosomes. A chromosomal aberration involving FGFR1OP may be a cause of stem cell myeloproliferative disorder (MPD). Translocation t(6;8)(q27;p11) with FGFR1. MPD is characterized by myeloid hyperplasia, eosinophilia and T-cell or B-cell lymphoblastic lymphoma. In general it progresses to acute myeloid leukemia. The fusion proteins FGFR1OP-FGFR1 or FGFR1-FGFR1OP may exhibit constitutive kinase activity and be responsible for the transforming activity. Belongs to the FGFR1OP family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Unknown function Chromosomal Location of Human Ortholog: 6q27 Cellular Component: centrosome; cytosol; nucleus; perinuclear region of cytoplasm Molecular Function:protein binding; protein homodimerization activity; protein kinase binding; protein tyrosine kinase inhibitor activity; protein-tyrosine kinase activity Biological Process: G2/M transition of mitotic cell cycle; negative regulation of protein kinase activity; positive regulation of cell growth; positive regulation of cell migration; positive regulation of cell proliferation |
| NCBI Summary: | This gene encodes a largely hydrophilic centrosomal protein that is required for anchoring microtubules to subcellular structures. A t(6;8)(q27;p11) chromosomal translocation, fusing this gene and the fibroblast growth factor receptor 1 (FGFR1) gene, has been found in cases of myeloproliferative disorder. The resulting chimeric protein contains the N-terminal leucine-rich region of this encoded protein fused to the catalytic domain of FGFR1. Alterations in this gene may also be associated with Crohn's disease, Graves' disease, and vitiligo. Alternatively spliced transcript variants that encode different proteins have been identified. [provided by RefSeq, Jul 2013] |
| UniProt Code: | O95684 |
| NCBI GenInfo Identifier: | 74762130 |
| NCBI Gene ID: | 11116 |
| NCBI Accession: | O95684.1 |
| UniProt Secondary Accession: | O95684,Q49AI0, Q5R3F6, Q96EW1, A8K1D1, B2R705, |
| UniProt Related Accession: | O95684 |
| Molecular Weight: | 16,106 Da |
| NCBI Full Name: | FGFR1 oncogene partner |
| NCBI Synonym Full Names: | FGFR1 oncogene partner |
| NCBI Official Symbol: | FGFR1OP |
| NCBI Official Synonym Symbols: | FOP |
| NCBI Protein Information: | FGFR1 oncogene partner |
| UniProt Protein Name: | FGFR1 oncogene partner |
| Protein Family: | FGFR1 oncogene partner |
| UniProt Gene Name: | FGFR1OP |
| UniProt Entry Name: | FR1OP_HUMAN |