| バックグラウンド: | The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene was identified by its oncogenic transforming activity. This gene and FGF3, another oncogenic growth factor, are located closely on chromosome 11. Co-amplification of both genes was found in various kinds of human tumors. Studies on the mouse homolog suggested a function in bone morphogenesis and limb development through the sonic hedgehog (SHH) signaling pathway. |
| UniProt Protein Function: | Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Required for normal limb and cardiac valve development during embryogenesis. |
| NCBI Summary: | The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene was identified by its oncogenic transforming activity. This gene and FGF3, another oncogenic growth factor, are located closely on chromosome 11. Co-amplification of both genes was found in various kinds of human tumors. Studies on the mouse homolog suggested a function in bone morphogenesis and limb development through the sonic hedgehog (SHH) signaling pathway. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P08620 |
| NCBI GenInfo Identifier: | 122750 |
| NCBI Gene ID: | 2249 |
| NCBI Accession: | P08620.1 |
| UniProt Secondary Accession: | P08620,B7U994, |
| UniProt Related Accession: | P08620,AAB21430 |
| Molecular Weight: | 12,237 Da |
| NCBI Full Name: | Fibroblast growth factor 4 |
| NCBI Synonym Full Names: | fibroblast growth factor 4 |
| NCBI Official Symbol: | FGF4 |
| NCBI Official Synonym Symbols: | HST; KFGF; HST-1; HSTF1; K-FGF; HBGF-4 |
| NCBI Protein Information: | fibroblast growth factor 4; FGF-4; HSTF-1; oncogene HST; kaposi sarcoma oncogene; transforming protein KS3; heparin-binding growth factor 4; heparin secretory transforming protein 1; heparin secretory-transforming protein 1; fibroblast growth factor 4 splice isoform; human stomach cancer, transforming factor from FGF-related oncogene |
| UniProt Protein Name: | Fibroblast growth factor 4 |
| UniProt Synonym Protein Names: | Heparin secretory-transforming protein 1; HST; HST-1; HSTF-1; Heparin-binding growth factor 4; HBGF-4; Transforming protein KS3 |
| Protein Family: | Fibroblast growth factor |
| UniProt Gene Name: | FGF4 |
| UniProt Entry Name: | FGF4_HUMAN |
