Anti-FGF17 Antibody (CAB17864)
- SKU:
- CAB17864
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-FGF17 Antibody |
| 抗体コード: | CAB17864 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IF |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 23-180 of human FGF17 (NP_003858.1). |
| 申し込み: | WB IF |
| 推奨希釈: | WB 1:500 - 1:1000 IF 1:50 - 1:200 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | SH-SY5Y, mouse testis, mouse brain, rat testis, rat brain |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 23-180 of human FGF17 (NP_003858.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | TQGE NHPS PNFN QYVR DQGA MTDQ LSRR QIRE YQLY SRTS GKHV QVTG RRIS ATAE DGNK FAKL IVET DTFG SRVR IKGA ESEK YICM NKRG KLIG KPSG KSKD CVFT EIVL ENNY TAFQ NARH EGWF MAFT RQGR PRQA SRSR QNQR EAHF IKRL YQ |
| 遺伝子ID: | 8822 |
| Uniprot: | O60258 |
| セルラーロケーション: | Secreted |
| 計算された分子量: | 23kDa/24kDa |
| 観察された分子量: | 24kDa |
| 同義語: | FGF17, FGF-13, FGF-17, HH20 |
| バックグラウンド: | This gene encodes a member of the fibroblast growth factor (FGF) family. Member of the FGF family possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes including embryonic development cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein is expressed during embryogenesis and in the adult cerebellum and cortex and may be essential for vascular growth and normal brain development. Mutations in this gene are the cause of hypogonadotropic hypogonadism 20 with or without anosmia. Alternate splicing results in multiple transcript variants. |
| UniProt Protein Function: | FGF17: Plays an important role in the regulation of embryonic development and as signaling molecule in the induction and patterning of the embryonic brain. Required for normal brain development. Belongs to the heparin-binding growth factors family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide; Cytokine Chromosomal Location of Human Ortholog: 8p21 Cellular Component: extracellular region; extracellular space Molecular Function:1-phosphatidylinositol-3-kinase activity; phosphatidylinositol-4,5-bisphosphate 3-kinase activity; protein-tyrosine kinase activity; Ras guanyl-nucleotide exchange factor activity; type 1 fibroblast growth factor receptor binding; type 2 fibroblast growth factor receptor binding Biological Process: cell-cell signaling; fibroblast growth factor receptor signaling pathway; MAPKKK cascade; nervous system development; phosphoinositide-mediated signaling; regulation of phosphoinositide 3-kinase cascade; signal transduction Disease: Hypogonadotropic Hypogonadism 20 With Or Without Anosmia |
| NCBI Summary: | This gene encodes a member of the fibroblast growth factor (FGF) family. Member of the FGF family possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes including embryonic development cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein is expressed during embryogenesis and in the adult cerebellum and cortex and may be essential for vascular growth and normal brain development. Mutations in this gene are the cause of hypogonadotropic hypogonadism 20 with or without anosmia. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015] |
| UniProt Code: | O60258 |
| NCBI GenInfo Identifier: | 6015147 |
| NCBI Gene ID: | 8822 |
| NCBI Accession: | O60258.1 |
| UniProt Secondary Accession: | O60258,Q2M2W1, B7ZLG4, |
| UniProt Related Accession: | O60258 |
| Molecular Weight: | 23,669 Da |
| NCBI Full Name: | Fibroblast growth factor 17 |
| NCBI Synonym Full Names: | fibroblast growth factor 17 |
| NCBI Official Symbol: | FGF17 |
| NCBI Official Synonym Symbols: | HH20; FGF-13; FGF-17 |
| NCBI Protein Information: | fibroblast growth factor 17 |
| UniProt Protein Name: | Fibroblast growth factor 17 |
| Protein Family: | Fibroblast growth factor |
| UniProt Gene Name: | FGF17 |
| UniProt Entry Name: | FGF17_HUMAN |
 | Western blot analysis of extracts of various cell lines, using FGF17 antibody (CAB17864) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 60s. |
 | Immunofluorescence analysis of mouse brain using FGF17 antibody (CAB17864) at dilution of 1:100. Blue: DAPI for nuclear staining. |
View AllClose