Anti-FGF14 Antibody (CAB6588)
- SKU:
- CAB6588
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-FGF14 Antibody |
| 抗体コード: | CAB6588 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IF |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-252 of human FGF14 (NP_787125.1). |
| 申し込み: | WB IF |
| 推奨希釈: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | U-937, Mouse brain, Mouse spleen, Rat brain |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-252 of human FGF14 (NP_787125.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | MVKP VPLF RRTD FKLL LCNH KDLF FLRV SKLL DCFS PKSM WFLW NIFS KGTH MLQC LCGK SLKK NKNP TDPQ LKGI VTRL YCRQ GYYL QMHP DGAL DGTK DDST NSTL FNLI PVGL RVVA IQGV KTGL YIAM NGEG YLYP SELF TPEC KFKE SVFE NYYV IYSS MLYR QQES GRAW FLGL NKEG QAMK GNRV KKTK PAAH FLPK PLEV AMYR EPSL HDVG ETVP KPGV TPSK STSA SAIM NGGK PVNK SKTT |
| 遺伝子ID: | 2259 |
| Uniprot: | Q92915 |
| セルラーロケーション: | Nucleus |
| 計算された分子量: | 27kDa/28kDa |
| 観察された分子量: | 28kDa |
| 同義語: | FGF14, FGF-14, FHF-4, FHF4, SCA27 |
| バックグラウンド: | The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. A mutation in this gene is associated with autosomal dominant cerebral ataxia. Alternatively spliced transcript variants have been found for this gene. |
| UniProt Protein Function: | FGF14: Probably involved in nervous system development and function. Defects in FGF14 are the cause of spinocerebellar ataxia type 27 (SCA27). Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA27 is an autosomal dominant cerebellar ataxia (ADCA). It is a slowly progressive disorder, with onset in late-childhood to early adulthood, characterized by ataxia with tremor, orofacial dyskinesia, psychiatric symptoms and cognitive deficits. Belongs to the heparin-binding growth factors family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Cytokine; Cell development/differentiation Chromosomal Location of Human Ortholog: 13q34 Cellular Component: extracellular region; nucleus Molecular Function:heparin binding; growth factor activity; fibroblast growth factor receptor binding Biological Process: nervous system development; synaptic transmission; fibroblast growth factor receptor signaling pathway; cell-cell signaling; adult locomotory behavior; neuromuscular process; JNK cascade; signal transduction Disease: Spinocerebellar Ataxia 27 |
| NCBI Summary: | The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. A mutation in this gene is associated with autosomal dominant cerebral ataxia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q92915 |
| NCBI GenInfo Identifier: | 2494463 |
| NCBI Gene ID: | 2259 |
| NCBI Accession: | Q92915.1 |
| UniProt Secondary Accession: | Q92915,Q86YN7, Q96QX6, |
| UniProt Related Accession: | Q92915 |
| Molecular Weight: | 247 |
| NCBI Full Name: | Fibroblast growth factor 14 |
| NCBI Synonym Full Names: | fibroblast growth factor 14 |
| NCBI Official Symbol: | FGF14 |
| NCBI Official Synonym Symbols: | FHF4; FHF-4; SCA27; FGF-14 |
| NCBI Protein Information: | fibroblast growth factor 14; bA397O8.2; fibroblast growth factor homologous factor 4 |
| UniProt Protein Name: | Fibroblast growth factor 14 |
| UniProt Synonym Protein Names: | Fibroblast growth factor homologous factor 4; FHF-4 |
| Protein Family: | Fibroblast growth factor |
| UniProt Gene Name: | FGF14 |
| UniProt Entry Name: | FGF14_HUMAN |
 | Western blot analysis of extracts of various cell lines, using FGF14 antibody (CAB6588) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
 | Immunofluorescence analysis of U2OS cells using FGF14 antibody (CAB6588). |
View AllClose