Anti-FGD1 Antibody (CAB16709)
- SKU:
- CAB16709
- Product type:
- Antibody
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
抗体名: | Anti-FGD1 Antibody |
抗体コード: | CAB16709 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB |
反応性: | Mouse, Rat |
宿主種: | Rabbit |
免疫原: | A synthetic peptide corresponding to a sequence within amino acids 700-800 of human FGD1 (NP_004454.2). |
申し込み: | WB |
推奨希釈: | WB 1:500 - 1:2000 |
反応性: | Mouse, Rat |
ポジティブサンプル: | mouse brain, mouse heart, rat brain |
免疫原: | A synthetic peptide corresponding to a sequence within amino acids 700-800 of human FGD1 (NP_004454.2). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | LLNS TNRE DEDT PPNS PNVD LGKR APTP IREK EVTM CMRC QEPF NSIT KRRH HCKA CGHV VCGK CSEF RARL VYDN NRSN RVCT DCYV ALHG VPGS SPAC S |
遺伝子ID: | 2245 |
Uniprot: | P98174 |
セルラーロケーション: | Cell projection, Cytoplasm, cytoskeleton, lamellipodium, ruffle |
計算された分子量: | 106kDa |
観察された分子量: | 110kDa |
同義語: | FGD1, AAS, FGDY, MRXS16, ZFYVE3, FYVE |
バックグラウンド: | This gene encodes a protein that contains Dbl (DH) and pleckstrin (PH) homology domains and is similar to the Rho family of small GTP-binding proteins. The encoded protein specifically binds to the Rho family GTPase Cdc42Hs and can stimulate the GDP-GTP exchange of the isoprenylated form of Cdc42Hs. It also stimulates the mitogen activated protein kinase cascade leading to c-Jun kinase SAPK/JNK1 activation. Defects in this gene are the cause of faciogenital dysplasia and X-linked mental retardation, syndromatic 16. |
NCBI Summary: | This gene encodes a protein that contains Dbl (DH) and pleckstrin (PH) homology domains and is similar to the Rho family of small GTP-binding proteins. The encoded protein specifically binds to the Rho family GTPase Cdc42Hs and can stimulate the GDP-GTP exchange of the isoprenylated form of Cdc42Hs. It also stimulates the mitogen activated protein kinase cascade leading to c-Jun kinase SAPK/JNK1 activation. Defects in this gene are the cause of the faciogenital dysplasia in Aarskog-Scott syndrome and a syndromatic form of X-linked cognitive disability. [provided by RefSeq, Jul 2017] |
UniProt Code: | P98174 |
NCBI GenInfo Identifier: | 24797153 |
NCBI Gene ID: | 2245 |
NCBI Accession: | NP_004454 |
UniProt Related Accession: | P98174 |
Molecular Weight: | 106kDa |
NCBI Full Name: | FYVE, RhoGEF and PH domain-containing protein 1 |
NCBI Synonym Full Names: | FYVE, RhoGEF and PH domain containing 1 |
NCBI Official Symbol: | FGD1 |
NCBI Official Synonym Symbols: | AAS; FGDY; MRXS16; ZFYVE3 |
NCBI Protein Information: | FYVE, RhoGEF and PH domain-containing protein 1 |
UniProt Protein Name: | FYVE, RhoGEF and PH domain-containing protein 1 |
UniProt Synonym Protein Names: | Faciogenital dysplasia 1 protein; Rho/Rac guanine nucleotide exchange factor FGD1; Rho/Rac GEF; Zinc finger FYVE domain-containing protein 3 |
Protein Family: | FYVE, RhoGEF and PH domain-containing protein |
UniProt Gene Name: | FGD1 |
UniProt Entry Name: | FGD1_HUMAN |
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