Anti-FEV Antibody (CAB17377)
- SKU:
- CAB17377
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Developmental Biology
Frequently bought together:
Description
| 抗体名: | Anti-FEV Antibody |
| 抗体コード: | CAB17377 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human |
| 宿主種: | Rabbit |
| 免疫原: | A synthetic peptide of human FEV. |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human |
| ポジティブサンプル: |
| 免疫原: | A synthetic peptide of human FEV. |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | Email for sequence |
| 遺伝子ID: | 54738 |
| Uniprot: | Q99581 |
| セルラーロケーション: | |
| 計算された分子量: | 25kDa |
| 観察された分子量: | Refer to figures |
| 同義語: | FEV, HSRNAFEV, PET-1 |
| バックグラウンド: | This gene belongs to the ETS transcription factor family. ETS family members have a highly conserved 85-amino acid ETS domain that binds purine-rich DNA sequences. The alanine-rich C-terminus of this gene indicates that it may act as a transcription repressor. This gene is exclusively expressed in neurons of the central serotonin (5-HT) system, a system implicated in the pathogeny of such psychiatric diseases as depression, anxiety, and eating disorders. In some types of Ewing tumors, this gene is fused to the Ewing sarcoma (EWS) gene following chromosome translocations. |
| UniProt Protein Function: | FEV: Functions as a transcriptional regulator. According to PubMed:12761502, it functions as a transcriptional repressor. Functions in the differentiation and the maintenance of the central serotonergic neurons. May play a role in cell growth. Genetic variation in FEV may be associated with susceptibility to sudden infant death syndrome (SIDS). SIDS remains elusive in its causes and devastating in its consequences. Despite the impressive decline in the incidence of SIDS since the recommendation to avoid the prone sleep position, SIDS remains a leading cause of death in the first year of life. A chromosomal aberration involving FEV is found in Ewing tumors. Translocation t(2;21;22)(q23;q22;q12) that forms a EWSR1-FEV fusion protein with a potential oncogenic activity. Belongs to the ETS family. |
| UniProt Protein Details: | Protein type:DNA-binding Chromosomal Location of Human Ortholog: 2q36 Cellular Component: nucleus Molecular Function:transcription corepressor activity; transcription factor activity Biological Process: cell differentiation; regulation of transcription from RNA polymerase II promoter; transcription from RNA polymerase II promoter |
| NCBI Summary: | This gene belongs to the ETS transcription factor family. ETS family members have a highly conserved 85-amino acid ETS domain that binds purine-rich DNA sequences. The alanine-rich C-terminus of this gene indicates that it may act as a transcription repressor. This gene is exclusively expressed in neurons of the central serotonin (5-HT) system, a system implicated in the pathogeny of such psychiatric diseases as depression, anxiety, and eating disorders. In some types of Ewing tumors, this gene is fused to the Ewing sarcoma (EWS) gene following chromosome translocations. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q99581 |
| NCBI GenInfo Identifier: | 74762701 |
| NCBI Gene ID: | 54738 |
| NCBI Accession: | Q99581.1 |
| UniProt Related Accession: | Q99581 |
| Molecular Weight: | 25,030 Da |
| NCBI Full Name: | Protein FEV |
| NCBI Synonym Full Names: | FEV, ETS transcription factor |
| NCBI Official Symbol: | FEV |
| NCBI Official Synonym Symbols: | PET-1; HSRNAFEV |
| NCBI Protein Information: | protein FEV |
| UniProt Protein Name: | Protein FEV |
| UniProt Synonym Protein Names: | Fifth Ewing variant protein; PC12 ETS domain-containing transcription factor 1; PC12 ETS factor 1; Pet-1 |
| Protein Family: | Protein |
| UniProt Gene Name: | FEV |
| UniProt Entry Name: | FEV_HUMAN |