| UniProt Protein Function: | Fes: a non-receptor tyrosine kinase of the Fer family. Appears to be involved in normal hematopoiesis as well as the development of acute promyelocytic leukemia. Contains one SH2 and one FCH domain. Four LOF point mutations seen in colorectal cancer. Orthologous to v-fes from feline leukemia virus and v-fps from avian transforming virus. Mutant forms are angiogenic. Promotes survival during differentiation, and may act both to promote and inhibit tumors. May be disrupted in the t(15q+;17q-) found in acute promyelocytic leukemia, but the breakpoint does not occur within the gene. |
| UniProt Protein Details: | Protein type:EC 2.7.10.2; Kinase, protein; Protein kinase, tyrosine (non-receptor); Protein kinase, TK; Oncoprotein; Tumor suppressor; TK group; Fer family Chromosomal Location of Human Ortholog: 15q26.1 Cellular Component: microtubule cytoskeleton; Golgi apparatus; extrinsic to internal side of plasma membrane; focal adhesion; cytoplasmic membrane-bound vesicle; cytoplasm; cytoplasmic vesicle; cytosol Molecular Function:protein binding; protein-tyrosine kinase activity; non-membrane spanning protein tyrosine kinase activity; phosphoinositide binding; ATP binding Biological Process: regulation of mast cell degranulation; epidermal growth factor receptor signaling pathway; regulation of cell adhesion; axon guidance; cell migration; peptidyl-tyrosine phosphorylation; positive regulation of myeloid cell differentiation; protein amino acid autophosphorylation; multicellular organismal development; positive regulation of microtubule polymerization; chemotaxis; protein amino acid phosphorylation; regulation of cell proliferation; cell proliferation; regulation of cell shape; regulation of cell differentiation; innate immune response |
| NCBI Summary: | This gene encodes the human cellular counterpart of a feline sarcoma retrovirus protein with transforming capabilities. The gene product has tyrosine-specific protein kinase activity and that activity is required for maintenance of cellular transformation. Its chromosomal location has linked it to a specific translocation event identified in patients with acute promyelocytic leukemia but it is also involved in normal hematopoiesis as well as growth factor and cytokine receptor signaling. Alternative splicing results in multiple variants encoding different isoforms.[provided by RefSeq, Jan 2009] |
| UniProt Code: | P07332 |
| NCBI GenInfo Identifier: | 115502390 |
| NCBI Gene ID: | 2242 |
| NCBI Accession: | P07332.3 |
| UniProt Secondary Accession: | P07332,Q2VXS7, Q2VXS8, Q2VXT0, Q6GTU5, B2R6E6, B4DUD0 E9PC94, E9PC95, |
| UniProt Related Accession: | P07332 |
| Molecular Weight: | 85,466 Da |
| NCBI Full Name: | Tyrosine-protein kinase Fes/Fps |
| NCBI Synonym Full Names: | FES proto-oncogene, tyrosine kinase |
| NCBI Official Symbol: | FES |
| NCBI Official Synonym Symbols: | FPS |
| NCBI Protein Information: | tyrosine-protein kinase Fes/Fps; p93c-fes; proto-oncogene c-Fes; proto-oncogene c-Fps; feline sarcoma oncogene; Oncogene FES, feline sarcoma virus; proto-oncogene tyrosine-protein kinase Fes/Fps; feline sarcoma/Fujinami avian sarcoma oncogene homolog; feline sarcoma (Snyder-Theilen) viral (v-fes)/Fujinami avian sarcoma (PRCII) viral (v-fps) oncogene homolog |
| UniProt Protein Name: | Tyrosine-protein kinase Fes/Fps |
| UniProt Synonym Protein Names: | Feline sarcoma/Fujinami avian sarcoma oncogene homolog; Proto-oncogene c-Fes; Proto-oncogene c-Fps; p93c-fes |
| Protein Family: | Festuclavine dehydrogenase |
| UniProt Gene Name: | FES |
| UniProt Entry Name: | FES_HUMAN |
