Anti-FCGR3B Antibody (CAB13980)

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SKU:
CAB13980
Product type:
Antibody
Reactivity:
Human
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology
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Description

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抗体名:Anti-FCGR3B Antibody
抗体コード:CAB13980
抗体サイズ:20uL, 50uL, 100uL
申し込み:WB IF
反応性:Human, Rat
宿主種:Rabbit
免疫原:Recombinant fusion protein containing a sequence corresponding to amino acids 1-233 of human FCGR3B (NP_000561.3).
申し込み:WB IF
推奨希釈:WB 1:500 - 1:2000 IF 1:50 - 1:200
反応性:Human, Rat
ポジティブサンプル:THP-1, Rat thymus
免疫原:Recombinant fusion protein containing a sequence corresponding to amino acids 1-233 of human FCGR3B (NP_000561.3).
精製方法:Affinity purification
ストレージバッファ:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
アイソタイプ:IgG
順序:MWQL LLPT ALLL LVSA GMRT EDLP KAVV FLEP QWYS VLEK DSVT LKCQ GAYS PEDN STQW FHNE NLIS SQAS SYFI DAAT VNDS GEYR CQTN LSTL SDPV QLEV HIGW LLLQ APRW VFKE EDPI HLRC HSWK NTAL HKVT YLQN GKDR KYFH HNSD FHIP KATL KDSG SYFC RGLV GSKN VSSE TVNI TITQ GLAV STIS SFSP PGYQ VSFC LVMV LLFA VDTG LYFS VKTN I
遺伝子ID:2215
Uniprot:O75015
セルラーロケーション:Cell membrane, GPI-anchor, Lipid-anchor, Secreted
計算された分子量:26kDa
観察された分子量:50kDa
同義語:FCGR3B, CD16, CD16b, FCG3, FCGR3, FCR-10, FCRIII, FCRIIIb
バックグラウンド:The protein encoded by this gene is a low affinity receptor for the Fc region of gamma immunoglobulins (IgG). The encoded protein acts as a monomer and can bind either monomeric or aggregated IgG. This gene may function to capture immune complexes in the peripheral circulation. Several transcript variants encoding different isoforms have been found for this gene. A highly-similar gene encoding a related protein is also found on chromosome 1.
UniProt Protein Function:Receptor for the Fc region of immunoglobulins gamma. Low affinity receptor. Binds complexed or aggregated IgG and also monomeric IgG. Contrary to III-A, is not capable to mediate antibody-dependent cytotoxicity and phagocytosis. May serve as a trap for immune complexes in the peripheral circulation which does not activate neutrophils.
NCBI Summary:The protein encoded by this gene is a low affinity receptor for the Fc region of gamma immunoglobulins (IgG). The encoded protein acts as a monomer and can bind either monomeric or aggregated IgG. This gene may function to capture immune complexes in the peripheral circulation. Several transcript variants encoding different isoforms have been found for this gene. A highly-similar gene encoding a related protein is also found on chromosome 1. [provided by RefSeq, Aug 2012]
UniProt Code:O75015
NCBI GenInfo Identifier:7994572
NCBI Gene ID:2215
NCBI Accession:O75015.2
UniProt Related Accession:O75015
Molecular Weight:
NCBI Full Name:Low affinity immunoglobulin gamma Fc region receptor III-B
NCBI Synonym Full Names:Fc fragment of IgG receptor IIIb
NCBI Official Symbol:FCGR3B  
NCBI Official Synonym Symbols:CD16; FCG3; CD16A; CD16b; FCGR3; FCGR3A; FCR-10; FCRIII; FCRIIIb  
NCBI Protein Information:low affinity immunoglobulin gamma Fc region receptor III-B
UniProt Protein Name:Low affinity immunoglobulin gamma Fc region receptor III-B
UniProt Synonym Protein Names:Fc-gamma RIII-beta; Fc-gamma RIII; Fc-gamma RIIIb; FcRIII; FcRIIIb; FcR-10; IgG Fc receptor III-1; CD_antigen: CD16b
UniProt Gene Name:FCGR3B  
Anti-FCGR3B Antibody (CAB13980)Western blot analysis of extracts of various cell lines, using FCGR3B antibody (CAB13980) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 60s.
Anti-FCGR3B Antibody (CAB13980)Immunofluorescence analysis of U2OS cells using FCGR3B antibody (CAB13980) at dilution of 1:100. Blue: DAPI for nuclear staining.
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