Anti-FCGR3A Antibody (CAB2552)
- SKU:
- CAB2552
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
抗体名: | Anti-FCGR3A Antibody |
抗体コード: | CAB2552 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB |
反応性: | Human, Mouse, Rat |
宿主種: | Rabbit |
免疫原: | A synthetic peptide corresponding to a sequence within amino acids 150-250 of human FCGR3A (NP_001121067.1). |
申し込み: | WB |
推奨希釈: | WB 1:500 - 1:2000 |
反応性: | Human, Mouse, Rat |
ポジティブサンプル: | LO2, Mouse liver, Rat liver |
免疫原: | A synthetic peptide corresponding to a sequence within amino acids 150-250 of human FCGR3A (NP_001121067.1). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | YFHH NSDF YIPK ATLK DSGS YFCR GLFG SKNV SSET VNIT ITQG LAVS TISS FFPP GYQV SFCL VMVL LFAV DTGL YFSV KTNI RSST RDWK DHKF KWRK D |
遺伝子ID: | 2214 |
Uniprot: | P08637 |
セルラーロケーション: | Cell membrane, Secreted, Single-pass type I membrane protein |
計算された分子量: | 29kDa |
観察された分子量: | 50kDa |
同義語: | CD16, CD16A, FCG3, FCGR3, FCGRIII, FCR-10, FCRIII, FCRIIIA, IGFR3, IMD20, FCGR3A |
バックグラウンド: | This gene encodes a receptor for the Fc portion of immunoglobulin G, and it is involved in the removal of antigen-antibody complexes from the circulation, as well as other other antibody-dependent responses. This gene (FCGR3A) is highly similar to another nearby gene (FCGR3B) located on chromosome 1. The receptor encoded by this gene is expressed on natural killer (NK) cells as an integral membrane glycoprotein anchored through a transmembrane peptide, whereas FCGR3B is expressed on polymorphonuclear neutrophils (PMN) where the receptor is anchored through a phosphatidylinositol (PI) linkage. Mutations in this gene have been linked to susceptibility to recurrent viral infections, susceptibility to systemic lupus erythematosus, and alloimmune neonatal neutropenia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
UniProt Protein Function: | FCGR3A: Receptor for the Fc region of IgG. Binds complexed or aggregated IgG and also monomeric IgG. Mediates antibody-dependent cellular cytotoxicity (ADCC) and other antibody-dependent responses, such as phagocytosis. |
UniProt Protein Details: | Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: 1q23 Cellular Component: integral to membrane; plasma membrane; external side of plasma membrane Molecular Function:IgG binding Biological Process: regulation of immune response; innate immune response; immune response Disease: Immunodeficiency 20 |
NCBI Summary: | This gene encodes a receptor for the Fc portion of immunoglobulin G, and it is involved in the removal of antigen-antibody complexes from the circulation, as well as other other antibody-dependent responses. This gene (FCGR3A) is highly similar to another nearby gene (FCGR3B) located on chromosome 1. The receptor encoded by this gene is expressed on natural killer (NK) cells as an integral membrane glycoprotein anchored through a transmembrane peptide, whereas FCGR3B is expressed on polymorphonuclear neutrophils (PMN) where the receptor is anchored through a phosphatidylinositol (PI) linkage. Mutations in this gene have been linked to susceptibility to recurrent viral infections, susceptibility to systemic lupus erythematosus, and alloimmune neonatal neutropenia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
UniProt Code: | P08637 |
NCBI GenInfo Identifier: | 119876 |
NCBI Gene ID: | 2214 |
NCBI Accession: | P08637.2 |
UniProt Secondary Accession: | P08637,Q53FJ0, Q53FL6, Q5EBR4, Q65ZM6, Q6PIJ0, A2N6W9 |
UniProt Related Accession: | P08637 |
Molecular Weight: | 254 |
NCBI Full Name: | Low affinity immunoglobulin gamma Fc region receptor III-A |
NCBI Synonym Full Names: | Fc fragment of IgG, low affinity IIIa, receptor (CD16a) |
NCBI Official Symbol: | FCGR3A |
NCBI Official Synonym Symbols: | CD16; FCG3; CD16A; FCGR3; IGFR3; IMD20; FCR-10; FCRIII; FCGRIII; FCRIIIA |
NCBI Protein Information: | low affinity immunoglobulin gamma Fc region receptor III-A; FcgammaRIIIA; CD16a antigen; fc-gamma RIII; Fc-gamma RIIIa; Fc-gamma RIII-alpha; igG Fc receptor III-2; Fc gamma receptor III-A; Fc-gamma receptor IIIb (CD16); neutrophil-specific antigen NA; Fc- |
UniProt Protein Name: | Low affinity immunoglobulin gamma Fc region receptor III-A |
UniProt Synonym Protein Names: | CD16a antigen; Fc-gamma RIII-alpha; Fc-gamma RIII; Fc-gamma RIIIa; FcRIII; FcRIIIa; FcR-10; IgG Fc receptor III-2; CD_antigen: CD16a |
Protein Family: | CD160 antigen |
UniProt Gene Name: | FCGR3A |
UniProt Entry Name: | FCG3A_HUMAN |
View AllClose