Anti-FCGR2C Antibody (CAB10062)
- SKU:
- CAB10062
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-FCGR2C Antibody |
| 抗体コード: | CAB10062 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 43-223 of human FCGR2C (NP_963857.3). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:1000 - 1:4000 |
| 反応性: | Human |
| ポジティブサンプル: | THP-1, 22Rv1 |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 43-223 of human FCGR2C (NP_963857.3). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | TPAA PPKA VLKL EPQW INVL QEDS VTLT CRGT HSPE SDSI PWFH NGNL IPTH TQPS YRFK ANNN DSGE YTCQ TGQT SLSD PVHL TVLS EWLV LQTP HLEF QEGE TIVL RCHS WKDK PLVK VTFF QNGK SKKF SRSD PNFS IPQA NHSH SGDY HCTG NIGY TLYS SKPV TITV QAPS SSPM G |
| 遺伝子ID: | 9103 |
| Uniprot: | P31995 |
| セルラーロケーション: | Cell membrane, Cytoplasm, Single-pass type I membrane protein |
| 計算された分子量: | 25kDa/29kDa/30kDa/35kDa |
| 観察された分子量: | 45kDa |
| 同義語: | FCGR2C, CD32, CD32C, CDW32, FCG2, FCRIIC, IGFR2 |
| バックグラウンド: |
| UniProt Protein Function: | FCGR2C: a transmembrane receptor for the Fc region of complexed or aggregated immunoglobulin gamma (IgG). Involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B-cells. Binding to this receptor results in down modulation of previous state of cell activation triggered via antigen receptors on B cells, T cells or via another Fc receptor. Three splice-variant isoforms have been observed. |
| UniProt Protein Details: | Protein type:Immunoglobulin superfamily; Membrane protein, integral Chromosomal Location of Human Ortholog: 1q23.3 Cellular Component: cytoplasm; plasma membrane; integral to membrane Molecular Function:protein binding; transmembrane receptor activity; IgG binding Biological Process: immune response; signal transduction Disease: Thrombocytopenic Purpura, Autoimmune |
| NCBI Summary: | This gene encodes one of three members of a family of low-affinity immunoglobulin gamma Fc receptors found on the surface of many immune response cells. The encoded protein is a transmembrane glycoprotein and may be involved in phagocytosis and clearing of immune complexes. An allelic polymorphism in this gene results in both coding and non-coding variants. [provided by RefSeq, Apr 2012] |
| UniProt Code: | P31995 |
| NCBI GenInfo Identifier: | 399478 |
| NCBI Gene ID: | 9103 |
| NCBI Accession: | P31995.1 |
| UniProt Secondary Accession: | P31995,O00523, O00524, O00525, |
| UniProt Related Accession: | P31995 |
| Molecular Weight: | 35,578 Da |
| NCBI Full Name: | Low affinity immunoglobulin gamma Fc region receptor II-c |
| NCBI Synonym Full Names: | Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene) |
| NCBI Official Symbol: | FCGR2C |
| NCBI Official Synonym Symbols: | CD32; FCG2; CD32C; CDW32; IGFR2; FCRIIC |
| NCBI Protein Information: | low affinity immunoglobulin gamma Fc region receptor II-c; fc-gamma-RIIc; IgG Fc receptor II-c; Fc gamma receptor IIC; immunoglobulin G Fc receptor II-c |
| UniProt Protein Name: | Low affinity immunoglobulin gamma Fc region receptor II-c |
| UniProt Synonym Protein Names: | CDw32; Fc-gamma RII-c |
| Protein Family: | Low affinity immunoglobulin gamma Fc region receptor |
| UniProt Gene Name: | FCGR2C |
| UniProt Entry Name: | FCG2C_HUMAN |
 | Western blot analysis of extracts of various cell lines, using FCGR2C antibody (CAB10062) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s. |
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