| バックグラウンド: | This gene is a member of the immunoglobulin gene superfamily and encodes a receptor for the Fc region of IgA. The receptor is a transmembrane glycoprotein present on the surface of myeloid lineage cells such as neutrophils, monocytes, macrophages, and eosinophils, where it mediates immunologic responses to pathogens. It interacts with IgA-opsonized targets and triggers several immunologic defense processes, including phagocytosis, antibody-dependent cell-mediated cytotoxicity, and stimulation of the release of inflammatory mediators. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene. |
| UniProt Protein Function: | Binds to the Fc region of immunoglobulins alpha. Mediates several functions including cytokine production. |
| NCBI Summary: | This gene is a member of the immunoglobulin gene superfamily and encodes a receptor for the Fc region of IgA. The receptor is a transmembrane glycoprotein present on the surface of myeloid lineage cells such as neutrophils, monocytes, macrophages, and eosinophils, where it mediates immunologic responses to pathogens. It interacts with IgA-opsonized targets and triggers several immunologic defense processes, including phagocytosis, antibody-dependent cell-mediated cytotoxicity, and stimulation of the release of inflammatory mediators. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P24071 |
| NCBI GenInfo Identifier: | 119860 |
| NCBI Gene ID: | 2204 |
| NCBI Accession: | P24071.1 |
| UniProt Related Accession: | P24071 |
| Molecular Weight: | |
| NCBI Full Name: | Immunoglobulin alpha Fc receptor |
| NCBI Synonym Full Names: | Fc fragment of IgA receptor |
| NCBI Official Symbol: | FCAR |
| NCBI Official Synonym Symbols: | CD89; FcalphaRI; CTB-61M7.2 |
| NCBI Protein Information: | immunoglobulin alpha Fc receptor |
| UniProt Protein Name: | Immunoglobulin alpha Fc receptor |
| UniProt Synonym Protein Names: | CD_antigen: CD89 |
| UniProt Gene Name: | FCAR |
