Anti-FBXO5 Antibody (CAB18449)
- SKU:
- CAB18449
- Product type:
- Antibody
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
Frequently bought together:
Description
| 抗体名: | Anti-FBXO5 Antibody |
| 抗体コード: | CAB18449 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant protein of human FBXO5. |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Mouse, Rat |
| ポジティブサンプル: |
| 免疫原: | Recombinant protein of human FBXO5. |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | Email for sequence |
| 遺伝子ID: | 26271 |
| Uniprot: | Q9UKT4 |
| セルラーロケーション: | |
| 計算された分子量: | |
| 観察された分子量: | Refer to figures |
| 同義語: | EMI1, FBX5, Fbxo31, FBXO5 |
| バックグラウンド: |
| UniProt Protein Function: | FBX5: a member of the SCFs class of F-box proteins. F-box proteins constitute one of the subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. FBX5 is an early mitotic inhibitor-1 (Emi1) that interacts with Cdc20 and inhibits the anaphase promoting complex (APC/C). APC/C is a ubiquitin ligase that targets mitotic regulatory proteins for degradation. FBX5 accumulates in the S phase and is rapidly degraded in prometaphase. |
| UniProt Protein Details: | Chromosomal Location of Human Ortholog: 6q25.2 Cellular Component: cytoplasm; cytosol; nucleoplasm; nucleus; spindle Molecular Function:protein binding; protein kinase binding Biological Process: G1/S transition of mitotic cell cycle; G1/S-specific transcription in mitotic cell cycle; negative regulation of meiosis; negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle; positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle; regulation of mitosis; regulation of mitotic cell cycle; regulation of ubiquitin-protein ligase activity during mitotic cell cycle |
| NCBI Summary: | This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. This protein is similar to xenopus early mitotic inhibitor-1 (Emi1), which is a mitotic regulator that interacts with Cdc20 and inhibits the anaphase promoting complex. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Dec 2008] |
| UniProt Code: | Q9UKT4 |
| NCBI GenInfo Identifier: | 24636847 |
| NCBI Gene ID: | 26271 |
| NCBI Accession: | Q9UKT4.1 |
| UniProt Secondary Accession: | Q9UKT4,Q5TF47, Q8WV29, Q9UGC8, B3KNX5, |
| UniProt Related Accession: | Q9UKT4 |
| Molecular Weight: | 45,353 Da |
| NCBI Full Name: | F-box only protein 5 |
| NCBI Synonym Full Names: | F-box protein 5 |
| NCBI Official Symbol: | FBXO5 |
| NCBI Official Synonym Symbols: | EMI1; FBX5; Fbxo31 |
| NCBI Protein Information: | F-box only protein 5 |
| UniProt Protein Name: | F-box only protein 5 |
| UniProt Synonym Protein Names: | Early mitotic inhibitor 1 |
| Protein Family: | F-box only protein |
| UniProt Gene Name: | FBXO5 |
| UniProt Entry Name: | FBX5_HUMAN |