Anti-FBXL2 Antibody (CAB10296)
- SKU:
- CAB10296
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Immunology
Frequently bought together:
Description
抗体名: | Anti-FBXL2 Antibody |
抗体コード: | CAB10296 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB |
反応性: | Human, Mouse, Rat |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 120-240 of human FBXL2 (NP_036289.3). |
申し込み: | WB |
推奨希釈: | WB 1:500 - 1:2000 |
反応性: | Human, Mouse, Rat |
ポジティブサンプル: | U-87MG, A-549, HT-1080, SKOV3, Mouse brain, Mouse kidney, Rat brain, Rat kidney |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 120-240 of human FBXL2 (NP_036289.3). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | STCY SLSR FCSK LKHL DLTS CVSI TNSS LKGI SEGC RNLE YLNL SWCD QITK DGIE ALVR GCRG LKAL LLRG CTQL EDEA LKHI QNYC HELV SLNL QSCS RITD EGVV QICR GCHR LQAL C |
遺伝子ID: | 25827 |
Uniprot: | Q9UKC9 |
セルラーロケーション: | Lipid-anchor, Membrane |
計算された分子量: | 39kDa/47kDa |
観察された分子量: | 38-47kDa |
同義語: | FBXL2, FBL2, FBL3 |
バックグラウンド: | This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains 12 tandem leucine-rich repeats. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
UniProt Protein Function: | FBXL2: Calcium-activated substrate recognition component of a SCF (SKP1-cullin-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Unlike many F-box proteins, FBXL2 doesn't seem to target phosphodegron within its substrates but rather calmodulin-binding motifs. Targets PCYT1A for its monoubiquitination and degradation, this is antagonized by calmodulin. Targets the cyclins CCND2 and CCND3 for polyubiquitination and degradation, leading to cell-cycle arrest in G(0), also antagonized by calmodulin. Binds to hepatitis C virus non-structural protein 5A (NS5A) in a reaction crucial for hepatitis C virus RNA replication. |
UniProt Protein Details: | Protein type:Ubiquitin ligase Chromosomal Location of Human Ortholog: 3p22.3 Cellular Component: cytoplasm; membrane; SCF ubiquitin ligase complex Molecular Function:protein binding; protein phosphatase binding; ubiquitin-protein ligase activity Biological Process: protein modification process; protein ubiquitination; proteolysis; regulation of autophagy; regulation of phosphoinositide 3-kinase cascade; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process |
NCBI Summary: | This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains 12 tandem leucine-rich repeats. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2010] |
UniProt Code: | Q9UKC9 |
NCBI GenInfo Identifier: | 145559475 |
NCBI Gene ID: | 25827 |
NCBI Accession: | Q9UKC9.3 |
UniProt Secondary Accession: | Q9UKC9,Q6IAN3, Q9NVQ8, Q9UK27, Q9UKA5, Q9Y3Y9, B4DQV0 E9PD06, |
UniProt Related Accession: | Q9UKC9 |
Molecular Weight: | 47kDa |
NCBI Full Name: | F-box/LRR-repeat protein 2 |
NCBI Synonym Full Names: | F-box and leucine rich repeat protein 2 |
NCBI Official Symbol: | FBXL2 |
NCBI Official Synonym Symbols: | FBL2; FBL3 |
NCBI Protein Information: | F-box/LRR-repeat protein 2 |
UniProt Protein Name: | F-box/LRR-repeat protein 2 |
UniProt Synonym Protein Names: | F-box and leucine-rich repeat protein 2 |
Protein Family: | F-box/LRR-repeat protein |
UniProt Gene Name: | FBXL2 |
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