Anti-FAP Antibody (CAB6349)
- SKU:
- CAB6349
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cardiovascular
Frequently bought together:
Description
| 抗体名: | Anti-FAP Antibody |
| 抗体コード: | CAB6349 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IF |
| 反応性: | Human, Mouse |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 26-280 of human FAP (NP_004451.2). |
| 申し込み: | WB IF |
| 推奨希釈: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| 反応性: | Human, Mouse |
| ポジティブサンプル: | Mouse heart |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 26-280 of human FAP (NP_004451.2). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | LRPS RVHN SEEN TMRA LTLK DILN GTFS YKTF FPNW ISGQ EYLH QSAD NNIV LYNI ETGQ SYTI LSNR TMKS VNAS NYGL SPDR QFVY LESD YSKL WRYS YTAT YYIY DLSN GEFV RGNE LPRP IQYL CWSP VGSK LAYV YQNN IYLK QRPG DPPF QITF NGRE NKIF NGIP DWVY EEEM LATK YALW WSPN GKFL AYAE FNDT DIPV IAYS YYGD EQYP RTIN IPYP KAGA KNPV VRIF IIDT TYPA YVGP QEV |
| 遺伝子ID: | 2191 |
| Uniprot: | Q12884 |
| セルラーロケーション: | Cell membrane, Cell projection, Cell surface, Cytoplasm, Membrane, Secreted, Single-pass type II membrane protein, Single-pass type II membrane protein, invadopodium membrane, lamellipodium membrane, ruffle membrane |
| 計算された分子量: | 26kDa/87kDa |
| 観察された分子量: | 88kDa |
| 同義語: | FAP, DPPIV, FAPA, FAPalpha, SIMP |
| バックグラウンド: | The protein encoded by this gene is a homodimeric integral membrane gelatinase belonging to the serine protease family. It is selectively expressed in reactive stromal fibroblasts of epithelial cancers, granulation tissue of healing wounds, and malignant cells of bone and soft tissue sarcomas. This protein is thought to be involved in the control of fibroblast growth or epithelial-mesenchymal interactions during development, tissue repair, and epithelial carcinogenesis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | FAP: In association with DPP4 is involved in the pericellular proteolysis of the extracellular matrix (ECM), the migration and invasion of endothelial cells into the ECM. May have a role in tissue remodeling during development and wound healing, and may contribute to invasiveness in malignant cancers. Belongs to the peptidase S9B family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:EC 3.4.14.5; Protease; EC 3.4.21.26; Membrane protein, integral Chromosomal Location of Human Ortholog: 2q23 Cellular Component: apical part of cell; cell surface; cytoplasm; extracellular space; focal adhesion; integral to membrane; lamellipodium; plasma membrane Molecular Function:dipeptidyl-peptidase activity; endopeptidase activity; integrin binding; metalloendopeptidase activity; peptidase activity; protease binding; protein binding; protein dimerization activity; protein homodimerization activity; serine-type endopeptidase activity; serine-type peptidase activity Biological Process: angiogenesis; cell adhesion; endothelial cell migration; proteolysis; proteolysis involved in cellular protein catabolic process; regulation of fibrinolysis |
| NCBI Summary: | The protein encoded by this gene is a homodimeric integral membrane gelatinase belonging to the serine protease family. It is selectively expressed in reactive stromal fibroblasts of epithelial cancers, granulation tissue of healing wounds, and malignant cells of bone and soft tissue sarcomas. This protein is thought to be involved in the control of fibroblast growth or epithelial-mesenchymal interactions during development, tissue repair, and epithelial carcinogenesis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2014] |
| UniProt Code: | Q12884 |
| NCBI GenInfo Identifier: | 292495099 |
| NCBI Gene ID: | 2191 |
| NCBI Accession: | Q12884.5 |
| UniProt Secondary Accession: | Q12884,O00199, Q53TP5, Q86Z29, Q99998, Q9UID4, |
| UniProt Related Accession: | Q12884 |
| Molecular Weight: | |
| NCBI Full Name: | Prolyl endopeptidase FAP |
| NCBI Synonym Full Names: | fibroblast activation protein alpha |
| NCBI Official Symbol: | FAP |
| NCBI Official Synonym Symbols: | FAPA; SIMP; DPPIV |
| NCBI Protein Information: | prolyl endopeptidase FAP |
| UniProt Protein Name: | Prolyl endopeptidase FAP |
| UniProt Synonym Protein Names: | 170 kDa melanoma membrane-bound gelatinase |
| Protein Family: | Prolyl endopeptidase |
| UniProt Gene Name: | FAP |
| UniProt Entry Name: | SEPR_HUMAN |
 | Western blot analysis of extracts of mouse heart, using FAP antibody (CAB6349) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
 | Immunofluorescence analysis of U2OS cells using FAP antibody (CAB6349) at dilution of 1:100. Blue: DAPI for nuclear staining. |
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