Anti-F13B Antibody (CAB18645)
- SKU:
- CAB18645
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
Frequently bought together:
Description
| 抗体名: | Anti-F13B Antibody |
| 抗体コード: | CAB18645 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant protein of human F13B. |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human |
| ポジティブサンプル: |
| 免疫原: | Recombinant protein of human F13B. |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | Email for sequence |
| 遺伝子ID: | 2165 |
| Uniprot: | P05160 |
| セルラーロケーション: | |
| 計算された分子量: | |
| 観察された分子量: | Refer to figures |
| 同義語: | |
| バックグラウンド: |
| UniProt Protein Function: | F13B: The B chain of factor XIII is not catalytically active, but is thought to stabilize the A subunits and regulate the rate of transglutaminase formation by thrombin. Defects in F13B are the cause of factor XIII subunit B deficiency (FA13BD). FA13BD is an autosomal recessive disorder characterized by a life-long bleeding tendency, impaired wound healing and spontaneous abortion in affected women. |
| UniProt Protein Details: | Protein type:Secreted, signal peptide; Secreted Chromosomal Location of Human Ortholog: 1q31-q32.1 Cellular Component: extracellular region Biological Process: blood coagulation Disease: Factor Xiii, B Subunit, Deficiency Of |
| NCBI Summary: | This gene encodes coagulation factor XIII B subunit. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, and the B subunits do not have enzymatic activity and may serve as a plasma carrier molecules. Platelet factor XIII is comprised only of 2 A subunits, which are identical to those of plasma origin. Upon activation by the cleavage of the activation peptide by thrombin and in the presence of calcium ion, the plasma factor XIII dissociates its B subunits and yields the same active enzyme, factor XIIIa, as platelet factor XIII. This enzyme acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, thus stabilizing the fibrin clot. Factor XIII deficiency is classified into two categories: type I deficiency, characterized by the lack of both the A and B subunits; and type II deficiency, characterized by the lack of the A subunit alone. These defects can result in a lifelong bleeding tendency, defective wound healing, and habitual abortion. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P05160 |
| NCBI GenInfo Identifier: | 145559473 |
| NCBI Gene ID: | 2165 |
| NCBI Accession: | P05160.3 |
| UniProt Secondary Accession: | P05160,Q5VYL5, A8K3E5, |
| UniProt Related Accession: | P05160 |
| Molecular Weight: | 75,511 Da |
| NCBI Full Name: | Coagulation factor XIII B chain |
| NCBI Synonym Full Names: | coagulation factor XIII B chain |
| NCBI Official Symbol: | F13B |
| NCBI Official Synonym Symbols: | FXIIIB |
| NCBI Protein Information: | coagulation factor XIII B chain |
| UniProt Protein Name: | Coagulation factor XIII B chain |
| UniProt Synonym Protein Names: | Fibrin-stabilizing factor B subunit; Protein-glutamine gamma-glutamyltransferase B chain; Transglutaminase B chain |
| Protein Family: | Coagulation factor |
| UniProt Gene Name: | F13B |
| UniProt Entry Name: | F13B_HUMAN |