Anti-F13A1 Antibody (CAB1461)
- SKU:
- CAB1461
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cardiovascular
Frequently bought together:
Description
| 抗体名: | Anti-F13A1 Antibody |
| 抗体コード: | CAB1461 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 600-732 of human F13A1 (NP_000120.2). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | Jurkat, SH-SY5Y, BxPC-3, Mouse testis, Rat brain, Rat testis |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 600-732 of human F13A1 (NP_000120.2). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | LEQA SLHF FVTA RINE TRDV LAKQ KSTV LTIP EIII KVRG TQVV GSDM TVTV EFTN PLKE TLRN VWVH LDGP GVTR PMKK MFRE IRPN STVQ WEEV CRPW VSGH RKLI ASMS SDSL RHVY GELD VQIQ RRPS M |
| 遺伝子ID: | 2162 |
| Uniprot: | P00488 |
| セルラーロケーション: | Cytoplasm, Secreted |
| 計算された分子量: | 83kDa |
| 観察された分子量: | 83kDa |
| 同義語: | F13A1, F13A |
| バックグラウンド: | This gene encodes the coagulation factor XIII A subunit. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, and the B subunits do not have enzymatic activity and may serve as plasma carrier molecules. Platelet factor XIII is comprised only of 2 A subunits, which are identical to those of plasma origin. Upon cleavage of the activation peptide by thrombin and in the presence of calcium ion, the plasma factor XIII dissociates its B subunits and yields the same active enzyme, factor XIIIa, as platelet factor XIII. This enzyme acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, thus stabilizing the fibrin clot. It also crosslinks alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin. Factor XIII deficiency is classified into two categories: type I deficiency, characterized by the lack of both the A and B subunits; and type II deficiency, characterized by the lack of the A subunit alone. These defects can result in a lifelong bleeding tendency, defective wound healing, and habitual abortion. |
| UniProt Protein Function: | F13A1: Factor XIII is activated by thrombin and calcium ion to a transglutaminase that catalyzes the formation of gamma-glutamyl- epsilon-lysine cross-links between fibrin chains, thus stabilizing the fibrin clot. Also cross-link alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin. Defects in F13A1 are the cause of factor XIII subunit A deficiency (FA13AD). FA13AD is an autosomal recessive disorder characterized by a life-long bleeding tendency, impaired wound healing and spontaneous abortion in affected women. Belongs to the transglutaminase superfamily. Transglutaminase family. |
| UniProt Protein Details: | Protein type:Transferase; EC 2.3.2.13 Chromosomal Location of Human Ortholog: 6p25.3-p24.3 Cellular Component: extracellular region Molecular Function:protein-glutamine gamma-glutamyltransferase activity; metal ion binding Biological Process: platelet activation; platelet degranulation; peptide cross-linking; blood coagulation Disease: Thrombophilia Due To Thrombin Defect; Myocardial Infarction, Susceptibility To; Factor Xiii, A Subunit, Deficiency Of |
| NCBI Summary: | This gene encodes the coagulation factor XIII A subunit. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, and the B subunits do not have enzymatic activity and may serve as plasma carrier molecules. Platelet factor XIII is comprised only of 2 A subunits, which are identical to those of plasma origin. Upon cleavage of the activation peptide by thrombin and in the presence of calcium ion, the plasma factor XIII dissociates its B subunits and yields the same active enzyme, factor XIIIa, as platelet factor XIII. This enzyme acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, thus stabilizing the fibrin clot. It also crosslinks alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin. Factor XIII deficiency is classified into two categories: type I deficiency, characterized by the lack of both the A and B subunits; and type II deficiency, characterized by the lack of the A subunit alone. These defects can result in a lifelong bleeding tendency, defective wound healing, and habitual abortion. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P00488 |
| NCBI GenInfo Identifier: | 119395709 |
| NCBI Gene ID: | 2162 |
| NCBI Accession: | NP_000120.2 |
| UniProt Secondary Accession: | P00488,Q59HA7, Q8N6X2, Q96P24, Q9BX29, |
| UniProt Related Accession: | P00488 |
| Molecular Weight: | 312,000 |
| NCBI Full Name: | coagulation factor XIII A chain |
| NCBI Synonym Full Names: | coagulation factor XIII, A1 polypeptide |
| NCBI Official Symbol: | F13A1 |
| NCBI Official Synonym Symbols: | F13A |
| NCBI Protein Information: | coagulation factor XIII A chain; TGase; factor XIIIa; fibrinoligase; FSF, A subunit; coagulation factor XIIIa; transglutaminase A chain; transglutaminase. plasma; fibrin stabilizing factor, A subunit; coagulation factor XIII, A polypeptide; protein-glutamine gamma-glutamyltransferase A chain; bA525O21.1 (coagulation factor XIII, A1 polypeptide) |
| UniProt Protein Name: | Coagulation factor XIII A chain |
| UniProt Synonym Protein Names: | Protein-glutamine gamma-glutamyltransferase A chain; Transglutaminase A chain |
| Protein Family: | 36 kDa major membrane protein |
| UniProt Gene Name: | F13A1 |
| UniProt Entry Name: | F13A_HUMAN |
 | Western blot analysis of extracts of various cell lines, using F13A1 antibody (CAB1461) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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