Anti-EXTL3 Antibody (CAB3857)
- SKU:
- CAB3857
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-EXTL3 Antibody |
| 抗体コード: | CAB3857 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IHC |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 52-220 of human EXTL3 (NP_001431.1). |
| 申し込み: | WB IHC |
| 推奨希釈: | WB 1:200 - 1:2000 IHC 1:50 - 1:200 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | 293T, Mouse pancreas, Rat lung |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 52-220 of human EXTL3 (NP_001431.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | TTLD EADE AGKR IFGP RVGN ELCE VKHV LDLC RIRE SVSE ELLQ LEAK RQEL NSEI AKLN LKIE ACKK SIEN AKQD LLQL KNVI SQTE HSYK ELMA QNQP KLSL PIRL LPEK DDAG LPPP KATR GCRL HNCF DYSR CPLT SGFP VYVY DSDQ FVFG SYLD PLVK QAFQ A |
| 遺伝子ID: | 2137 |
| Uniprot: | O43909 |
| セルラーロケーション: | Endoplasmic reticulum membrane, Single-pass type II membrane protein |
| 計算された分子量: | 104kDa |
| 観察された分子量: | 105kDa |
| 同義語: | EXTL3, BOTV, EXTL1L, EXTR1, REGR, RPR, ISDNA |
| バックグラウンド: | This gene encodes a single-pass membrane protein which functions as a glycosyltransferase. The encoded protein catalyzes the transfer of N-acetylglucosamine to glycosaminoglycan chains. This reaction is important in heparin and heparan sulfate synthesis. Alternative splicing results in the multiple transcript variants. |
| UniProt Protein Function: | EXTL3: Probable glycosyltransferase. Belongs to the glycosyltransferase 47 family. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Transferase; EC 2.4.1.223; Glycan Metabolism - heparan sulfate biosynthesis Chromosomal Location of Human Ortholog: 8p21 Cellular Component: endoplasmic reticulum membrane; endoplasmic reticulum; integral to membrane Molecular Function:metal ion binding; glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity Biological Process: glycosaminoglycan biosynthetic process; cellular protein metabolic process; unfolded protein response, activation of signaling protein activity; unfolded protein response; heparan sulfate proteoglycan biosynthetic process; positive regulation of cell growth |
| NCBI Summary: | This gene encodes a single-pass membrane protein which functions as a glycosyltransferase. The encoded protein catalyzes the transfer of N-acetylglucosamine to glycosaminoglycan chains. This reaction is important in heparin and heparan sulfate synthesis. Alternative splicing results in the multiple transcript variants. [provided by RefSeq, Nov 2012] |
| UniProt Code: | O43909 |
| NCBI GenInfo Identifier: | 6166159 |
| NCBI Gene ID: | 2137 |
| NCBI Accession: | O43909.1 |
| UniProt Secondary Accession: | O43909,O00225, Q53XT3, D3DST8, |
| UniProt Related Accession: | O43909 |
| Molecular Weight: | Observed MW 105kDaCalculated MW 104kDa |
| NCBI Full Name: | Exostosin-like 3 |
| NCBI Synonym Full Names: | exostosin-like glycosyltransferase 3 |
| NCBI Official Symbol: | EXTL3 |
| NCBI Official Synonym Symbols: | RPR; BOTV; REGR; EXTR1; EXTL1L |
| NCBI Protein Information: | exostosin-like 3; reg receptor; EXT-related 1; exostosin tumor-like 3; exostoses (multiple)-like 3; putative tumor suppressor protein EXTL3; hereditary multiple exostoses gene isolog; glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase |
| UniProt Protein Name: | Exostosin-like 3 |
| UniProt Synonym Protein Names: | EXT-related protein 1; Glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase; Hereditary multiple exostoses gene isolog; Multiple exostosis-like protein 3; Putative tumor suppressor protein EXTL3 |
| Protein Family: | Exostosin |
| UniProt Gene Name: | EXTL3 |
| UniProt Entry Name: | EXTL3_HUMAN |
 | Western blot analysis of extracts of various cell lines, using EXTL3 antibody (CAB3857) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5s. |
 | Immunohistochemistry of paraffin-embedded rat kidney using EXTL3 Rabbit pAb (CAB3857) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded mouse kidney using EXTL3 Rabbit pAb (CAB3857) at dilution of 1:100 (40x lens). |
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