Anti-EXOSC5 Antibody (CAB15870)
- SKU:
- CAB15870
- Product type:
- Antibody
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Frequently bought together:
Description
| 抗体名: | Anti-EXOSC5 Antibody |
| 抗体コード: | CAB15870 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-235 of human EXOSC5 (NP_064543.3). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Rat |
| ポジティブサンプル: | Rat pancreas |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-235 of human EXOSC5 (NP_064543.3). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | MEEE THTD AKIR AENG TGSS PRGP GCSL RHFA CEQN LLSR PDGS ASFL QGDT SVLA GVYG PAEV KVSK EIFN KATL EVIL RPKI GLPG VAEK SRER LIRN TCEA VVLG TLHP RTSI TVVL QVVS DAGS LLAC CLNA ACMA LVDA GVPM RALF CGVA CALD SDGT LVLD PTSK QEKE ARAV LTFA LDSV ERKL LMSS TKGL YSDT ELQQ CLAA AQAA SQHV FRFY RESL QRRY SKS |
| 遺伝子ID: | 56915 |
| Uniprot: | Q9NQT4 |
| セルラーロケーション: | Cytoplasm, Nucleus, nucleolus |
| 計算された分子量: | 25kDa |
| 観察された分子量: | 25kDa |
| 同義語: | EXOSC5, RRP41B, RRP46, Rrp46p, hRrp46p, p12B |
| バックグラウンド: |
| UniProt Protein Function: | EXOSC5: Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. Belongs to the RNase PH family. |
| UniProt Protein Details: | Protein type:Ribonuclease; Nucleolus; EC 3.1.13.- Chromosomal Location of Human Ortholog: 19q13.1 Cellular Component: cytoplasm; nucleolus; exosome (RNase complex); nucleus; cytosol Molecular Function:protein binding; 3'-5'-exoribonuclease activity; exoribonuclease activity; RNA binding Biological Process: gene expression; DNA deamination; defense response to virus; rRNA processing; mRNA catabolic process, deadenylation-dependent decay |
| UniProt Code: | Q9NQT4 |
| NCBI GenInfo Identifier: | 14285757 |
| NCBI Gene ID: | 56915 |
| NCBI Accession: | Q9NQT4.1 |
| UniProt Related Accession: | Q9NQT4 |
| Molecular Weight: | Calculated: 25kDaObserved: 25kDa |
| NCBI Full Name: | Exosome complex component RRP46 |
| NCBI Synonym Full Names: | exosome component 5 |
| NCBI Official Symbol: | EXOSC5 |
| NCBI Official Synonym Symbols: | p12B; RRP46; RRP41B; Rrp46p; hRrp46p |
| NCBI Protein Information: | exosome complex component RRP46 |
| UniProt Protein Name: | Exosome complex component RRP46 |
| UniProt Synonym Protein Names: | Chronic myelogenous leukemia tumor antigen 28; Exosome component 5; Ribosomal RNA-processing protein 46; p12B |
| Protein Family: | Exosome complex component |
| UniProt Gene Name: | EXOSC5 |
| UniProt Entry Name: | EXOS5_HUMAN |
 | Western blot analysis of extracts of rat pancreas, using EXOSC5 antibody (CAB15870) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 60s. |
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