Anti-EXOSC4 Antibody (CAB9147)
- SKU:
- CAB9147
- Product type:
- Antibody
- Application:
- WB
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Epigenetics and Nuclear Signaling
Frequently bought together:
Description
抗体名: | Anti-EXOSC4 Antibody |
抗体コード: | CAB9147 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB IHC |
反応性: | Human, Rat |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-245 of human EXOSC4 (NP_061910.1). |
申し込み: | WB IHC |
推奨希釈: | WB 1:500 - 1:2000 IHC 1:100 - 1:200 |
反応性: | Human, Rat |
ポジティブサンプル: | HeLa, A-431, Jurkat, LO2 |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-245 of human EXOSC4 (NP_061910.1). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | MAGL ELLS DQGY RVDG RRAG ELRK IQAR MGVF AQAD GSAY IEQG NTKA LAVV YGPH EIRG SRAR ALPD RALV NCQY SSAT FSTG ERKR RPHG DRKS CEMG LQLR QTFE AAIL TQLH PRSQ IDIY VQVL QADG GTYA ACVN AATL AVLD AGIP MRDF VCAC SAGF VDGT ALAD LSHV EEAA GGPQ LALA LLPA SGQI ALLE MDAR LHED HLER VLEA AAQA ARDV HTLL DRVV RQHV REAS ILLG D |
遺伝子ID: | 54512 |
Uniprot: | Q9NPD3 |
セルラーロケーション: | Cytoplasm, Nucleus, nucleolus |
計算された分子量: | 26kDa |
観察された分子量: | 26kDa |
同義語: | EXOSC4, RRP41, RRP41A, Rrp41p, SKI6, Ski6p, hRrp41p, p12A |
バックグラウンド: |
UniProt Protein Function: | EXOSC4: Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC4 binds to ARE-containing RNAs. Belongs to the RNase PH family. |
UniProt Protein Details: | Protein type:Ribonuclease; Nucleolus; EC 3.1.13.- Chromosomal Location of Human Ortholog: 8q24.3 Cellular Component: cytoplasm; cytosol; exosome (RNase complex); nuclear exosome (RNase complex); nucleolus; nucleoplasm; nucleus Molecular Function:AU-rich element binding; exoribonuclease activity; protein binding Biological Process: defense response to virus; DNA deamination; maturation of 5.8S rRNA; positive regulation of cell growth; regulation of mRNA stability; rRNA 3'-end processing; rRNA catabolic process; rRNA processing |
UniProt Code: | Q9NPD3 |
NCBI GenInfo Identifier: | 14285756 |
NCBI Gene ID: | 54512 |
NCBI Accession: | Q9NPD3.3 |
UniProt Related Accession: | Q9NPD3 |
Molecular Weight: | 26,383 Da |
NCBI Full Name: | Exosome complex component RRP41 |
NCBI Synonym Full Names: | exosome component 4 |
NCBI Official Symbol: | EXOSC4 |
NCBI Official Synonym Symbols: | SKI6; p12A; RRP41; Ski6p; RRP41A; Rrp41p; hRrp41p |
NCBI Protein Information: | exosome complex component RRP41 |
UniProt Protein Name: | Exosome complex component RRP41 |
UniProt Synonym Protein Names: | Exosome component 4; Ribosomal RNA-processing protein 41; p12A |
UniProt Gene Name: | EXOSC4 |
UniProt Entry Name: | EXOS4_HUMAN |
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