Anti-EVPL Antibody (CAB10215)
- SKU:
- CAB10215
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-EVPL Antibody |
| 抗体コード: | CAB10215 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IHC |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1784-2033 of human EVPL (NP_001979.2). |
| 申し込み: | WB IHC |
| 推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | HeLa, Mouse lung, Rat lung |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1784-2033 of human EVPL (NP_001979.2). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | TKPS SSLS IGSI ISKS PLAS PAPQ STSF FSPS FSLG LGDD SFPI AGIY DTTT DNKC SIKT AVAK NMLD PITG QKLL EAQA ATGG IVDL LSRE RYSV HKAM ERGL IENT STQR LLNA QKAF TGIE DPVT KKRL SVGE AVQK GWMP RESV LPHL QVQH LTGG LIDP KRTG RIPI QQAL LSGM ISEE LAQL LQDE SSYE KDLT DPIS KERL SYKE AMGR CRKD PLSG LLLL PAAL EGYR CYRS ASPT VPRS LR |
| 遺伝子ID: | 2125 |
| Uniprot: | Q92817 |
| セルラーロケーション: | Cell junction, Cornified envelope, Cytoplasm, cytoskeleton, desmosome |
| 計算された分子量: | 231kDa |
| 観察された分子量: | 270kDa |
| 同義語: | EVPL, EVPK |
| バックグラウンド: | This gene encodes a member of the plakin family of proteins that forms a component of desmosomes and the epidermal cornified envelope. This gene is located in the tylosis oesophageal cancer locus on chromosome 17q25, and its deletion is associated with both familial and sporadic forms of oesophageal squamous cell carcinoma. Patients suffering from the autoimmune mucocutaneous disorder, paraneoplastic pemphigus, develop antibodies against the encoded protein. |
| UniProt Protein Function: | envoplakin: Component of the cornified envelope of keratinocytes. May link the cornified envelope to desmosomes and intermediate filaments. Belongs to the plakin or cytolinker family. |
| UniProt Protein Details: | Protein type:Adaptor/scaffold Chromosomal Location of Human Ortholog: 17q25.1 Cellular Component: cornified envelope; cytosol; intermediate filament cytoskeleton Molecular Function:cadherin binding; protein binding, bridging; structural molecule activity Biological Process: epidermis development; keratinocyte differentiation; peptide cross-linking |
| NCBI Summary: | This gene encodes a member of the plakin family of proteins that forms a component of desmosomes and the epidermal cornified envelope. This gene is located in the tylosis oesophageal cancer locus on chromosome 17q25, and its deletion is associated with both familial and sporadic forms of oesophageal squamous cell carcinoma. Patients suffering from the autoimmune mucocutaneous disorder, paraneoplastic pemphigus, develop antibodies against the encoded protein. [provided by RefSeq, Jul 2016] |
| UniProt Code: | Q92817 |
| NCBI GenInfo Identifier: | 296439359 |
| NCBI Gene ID: | 2125 |
| NCBI Accession: | Q92817.3 |
| UniProt Secondary Accession: | Q92817,A0AUV5, |
| UniProt Related Accession: | Q92817 |
| Molecular Weight: | 232kDa |
| NCBI Full Name: | Envoplakin |
| NCBI Synonym Full Names: | envoplakin |
| NCBI Official Symbol: | EVPL |
| NCBI Official Synonym Symbols: | EVPK |
| NCBI Protein Information: | envoplakin |
| UniProt Protein Name: | Envoplakin |
| UniProt Synonym Protein Names: | 210 kDa cornified envelope precursor protein; 210 kDa paraneoplastic pemphigus antigen; p210 |
| Protein Family: | Envoplakin |
| UniProt Gene Name: | EVPL |
 | Western blot analysis of extracts of various cell lines, using EVPL antibody (CAB10215) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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