Anti-ESPN Antibody (CAB15908)
- SKU:
- CAB15908
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-ESPN Antibody |
| 抗体コード: | CAB15908 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IHC |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 585-854 of human ESPN (NP_113663.2). |
| 申し込み: | WB IHC |
| 推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | Mouse testis, Rat testis |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 585-854 of human ESPN (NP_113663.2). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | CAAD PKAS RELP PPPP PPPP PLPE AASS PPPA PPLP LESA GPGC GQRR SSSS TGST KSFN MMSP TGDN SELL AEIK AGKS LKPT PQSK GLTT VFSG IGQP AFQP DSPL PSVS PALS PVRS PTPP AAGF QPLL NGSL VPVP PTTP APGV QLDV EALI PTHD EQGR PIPE WKRQ VMVR KMQL KMQE EEEQ RRKE EEEE ARLA SMPA WRRD LLRK KLEE EREQ KRKE EERQ KQEE LRRE KEQS EKLR TLGY DESK LAPW QRQV ILKK GDIA KY |
| 遺伝子ID: | 83715 |
| Uniprot: | B1AK53 |
| セルラーロケーション: | Cell projection, Cytoplasm, cytoskeleton, microvillus, stereocilium |
| 計算された分子量: | 31kDa/91kDa |
| 観察された分子量: | 110-120kDa |
| 同義語: | ESPN, DFNB36, LP2654, espin |
| バックグラウンド: | This gene encodes a multifunctional actin-bundling protein. It plays a major role in regulating the organization, dimensions, dynamics, and signaling capacities of the actin filament-rich, microvillus-type specializations that mediate sensory transduction in various mechanosensory and chemosensory cells. Mutations in this gene are associated with autosomal recessive neurosensory deafness, and autosomal dominant sensorineural deafness without vestibular involvement. |
| UniProt Protein Function: | ESPN: Multifunctional actin-bundling protein. Plays a major role in regulating the organization, dimensions, dynamics and signaling capacities of the actin filament-rich, microvillus-type specializations that mediate sensory transduction in variouS mechanosensory and chemosensory cells. Defects in ESPN are the cause of deafness autosomal recessive type 36 with or without vestibular involvement (DFNB36). A form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Actin-binding; Cytoskeletal Chromosomal Location of Human Ortholog: 1p36.31 Cellular Component: brush border; filamentous actin Molecular Function:actin filament binding; SH3 domain binding Disease: Deafness, Autosomal Recessive 36, With Or Without Vestibular Involvement |
| NCBI Summary: | This gene encodes a multifunctional actin-bundling protein. It plays a major role in regulating the organization, dimensions, dynamics, and signaling capacities of the actin filament-rich, microvillus-type specializations that mediate sensory transduction in various mechanosensory and chemosensory cells. Mutations in this gene are associated with autosomal recessive neurosensory deafness, and autosomal dominant sensorineural deafness without vestibular involvement. [provided by RefSeq, Nov 2009] |
| UniProt Code: | B1AK53 |
| NCBI GenInfo Identifier: | 189037868 |
| NCBI Gene ID: | 83715 |
| NCBI Accession: | B1AK53.1 |
| UniProt Secondary Accession: | B1AK53,Q6XYB2, Q9H0A2, Q9Y329, |
| UniProt Related Accession: | B1AK53 |
| Molecular Weight: | 31,636 Da |
| NCBI Full Name: | Espin |
| NCBI Synonym Full Names: | espin |
| NCBI Official Symbol: | ESPN |
| NCBI Official Synonym Symbols: | DFNB36; LP2654 |
| NCBI Protein Information: | espin |
| UniProt Protein Name: | Espin |
| UniProt Synonym Protein Names: | Autosomal recessive deafness type 36 protein; Ectoplasmic specialization protein |
| Protein Family: | Espin |
| UniProt Gene Name: | ESPN |
| UniProt Entry Name: | ESPN_HUMAN |
 | Western blot analysis of extracts of various cell lines, using ESPN antibody (CAB15908) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s. |
 | Immunohistochemistry of paraffin-embedded Human colon carcinoma using ESPN Rabbit pAb (CAB15908) at dilution of 1:100 (40x lens). |
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