| UniProt Protein Function: | ELF3: Transcriptional activator that binds and transactivates ETS sequences containing the consensus nucleotide core sequence GGA[AT]. Acts synergistically with POU2F3 to transactivate the SPRR2A promoter and with RUNX1 to transactivate the ANGPT1 promoter. Also transactivates collagenase, CCL20, CLND7, FLG, KRT8, NOS2, PTGS2, SPRR2B, TGFBR2 and TGM3 promoters. Represses KRT4 promoter activity. Involved in mediating vascular inflammation. May play an important role in epithelial cell differentiation and tumorigenesis. May be a critical downstream effector of the ERBB2 signaling pathway. May be associated with mammary gland development and involution. Plays an important role in the regulation of transcription with TATA-less promoters in preimplantation embryos, which is essential in preimplantation development. Belongs to the ETS family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Transcription factor; Motility/polarity/chemotaxis; DNA-binding Chromosomal Location of Human Ortholog: 1q32.2 Cellular Component: cytoplasm; nucleus Molecular Function:protein binding; transcription coactivator activity; transcription factor activity Biological Process: transcription from RNA polymerase II promoter; regulation of transcription from RNA polymerase II promoter; mammary gland involution; epidermis development; extracellular matrix organization and biogenesis; blastocyst development; epithelial cell differentiation; positive regulation of transcription, DNA-dependent; multicellular organismal development; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; inflammatory response |
| UniProt Code: | P78545 |
| NCBI GenInfo Identifier: | 74739735 |
| NCBI Gene ID: | 1999 |
| NCBI Accession: | P78545.1 |
| UniProt Secondary Accession: | P78545,Q6IAP8, Q7RU03, Q7Z3X2, Q8NFG2, Q99718, B2R5Q6 |
| UniProt Related Accession: | P78545 |
| Molecular Weight: | |
| NCBI Full Name: | ETS-related transcription factor Elf-3 |
| NCBI Synonym Full Names: | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) |
| NCBI Official Symbol: | ELF3 |
| NCBI Official Synonym Symbols: | ERT; ESX; EPR-1; ESE-1 |
| NCBI Protein Information: | ETS-related transcription factor Elf-3; ELF3; epithelial-restricted with serine box; epithelium-restricted Ets protein ESX; epithelium-specific Ets transcription factor 1; E74-like factor 3 (ets domain transcription factor); ets domain transcription factor, serine box (epithelial-specific); E74-like factor 3 (ETS domain transcription factor, serine box, epithelial-specific) |
| UniProt Protein Name: | ETS-related transcription factor Elf-3 |
| UniProt Synonym Protein Names: | E74-like factor 3; Epithelial-restricted with serine box; Epithelium-restricted Ets protein ESX; Epithelium-specific Ets transcription factor 1; ESE-1 |
| Protein Family: | ELF3-like protein |
| UniProt Gene Name: | ELF3 |
| UniProt Entry Name: | ELF3_HUMAN |
