Anti-ERO1LB Antibody (CAB3682)
- SKU:
- CAB3682
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
抗体名: | Anti-ERO1LB Antibody |
抗体コード: | CAB3682 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB |
反応性: | Human, Mouse |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 34-230 of human ERO1LB (NP_063944.3). |
申し込み: | WB |
推奨希釈: | WB 1:500 - 1:2000 |
反応性: | Human, Mouse |
ポジティブサンプル: | U-87MG, DU145, Mouse liver |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 34-230 of human ERO1LB (NP_063944.3). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | QVTG VLDD CLCD IDSI DNFN TYKI FPKI KKLQ ERDY FRYY KVNL KRPC PFWA EDGH CSIK DCHV EPCP ESKI PVGI KAGH SNKY LKMA NNTK ELED CEQA NKLG AINS TLSN QSKE AFID WARY DDSR DHFC ELDD ERSP AAQY VDLL LNPE RYTG YKGT SAWR VWNS IYEE NCFK PRSV YRPL NPLA PSRG EDDG E |
遺伝子ID: | 56605 |
Uniprot: | Q86YB8 |
セルラーロケーション: | Endoplasmic reticulum membrane, Lumenal side, Peripheral membrane protein |
計算された分子量: | 16kDa/53kDa |
観察された分子量: | 48kDa |
同義語: | ERO1B, ERO1LB, Ero1beta |
バックグラウンド: |
UniProt Protein Function: | ERO1LB: Essential oxidoreductase that oxidizes proteins in the endoplasmic reticulum to produce disulfide bonds. Acts by oxidizing directly P4HB/PDI isomerase through a direct disulfide exchange. Does not act as a direct oxidant of folding substrate, but relies on P4HB/PDI to transfer oxidizing equivalent. Associates with ERP44 but not with GRP54, demonstrating that it does not oxidize all PDI related proteins and can discriminate between PDI and related proteins. Its reoxidation probably involves electron transfer to molecular oxygen via FAD. Acts independently of glutathione. May be responsible for a significant proportion of reactive oxygen species (ROS) in the being a source of oxidative stress. Required for the folding of cell, thereby being a source of oxidative stress. Belongs to the EROs family. |
UniProt Protein Details: | Protein type:Oxidoreductase; EC 1.8.4.-; Endoplasmic reticulum Chromosomal Location of Human Ortholog: 1q42.2-q43 Cellular Component: endoplasmic reticulum membrane; endoplasmic reticulum Molecular Function:protein binding; unfolded protein binding; protein disulfide oxidoreductase activity; protein disulfide isomerase activity; oxidoreductase activity; oxidoreductase activity, acting on sulfur group of donors, disulfide as acceptor Biological Process: insulin processing; protein maturation via protein folding; extracellular matrix organization and biogenesis; 4-hydroxyproline metabolic process; protein folding; cell redox homeostasis; glucose homeostasis |
UniProt Code: | Q86YB8 |
NCBI GenInfo Identifier: | 116241353 |
NCBI Gene ID: | 56605 |
NCBI Accession: | Q86YB8.2 |
UniProt Secondary Accession: | Q86YB8,Q5T1H4, Q8IZ11, Q9NR62, B4DF57, |
UniProt Related Accession: | Q86YB8 |
Molecular Weight: | |
NCBI Full Name: | ERO1-like protein beta |
NCBI Synonym Full Names: | ERO1-like beta (S. cerevisiae) |
NCBI Official Symbol: | ERO1LB |
NCBI Protein Information: | ERO1-like protein beta; ERO1-L-beta; endoplasmic oxidoreductin-1-like protein B; endoplasmic reticulum oxidoreductin-1-like protein B; oxidoreductin-1-L-beta |
UniProt Protein Name: | ERO1-like protein beta |
UniProt Synonym Protein Names: | Endoplasmic reticulum oxidoreductin-1-like protein B; Oxidoreductin-1-L-beta |
UniProt Gene Name: | ERO1LB |
UniProt Entry Name: | ERO1B_HUMAN |
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