Anti-EREG Antibody (CAB16372)
- SKU:
- CAB16372
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cardiovascular
Description
| 抗体名: | Anti-EREG Antibody |
| 抗体コード: | CAB16372 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | A synthetic peptide corresponding to a sequence within amino acids 100 to the C-terminus of human EREG (NP_001423.1). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: |
| 免疫原: | A synthetic peptide corresponding to a sequence within amino acids 100 to the C-terminus of human EREG (NP_001423.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | GVRC EHFF LTVH QPLS KEYV ALTV ILII LFLI TVVG STYY FCRW YRNR KSKE PKKE YERV TSGD PELP QV |
| 遺伝子ID: | 2069 |
| Uniprot: | O14944 |
| セルラーロケーション: | Cell membrane, Secreted, Single-pass type I membrane protein, extracellular space |
| 計算された分子量: | 19kDa |
| 観察された分子量: | Refer to figures |
| 同義語: | EREG, EPR, ER, Ep |
| バックグラウンド: | This gene encodes a secreted peptide hormone and member of the epidermal growth factor (EGF) family of proteins. The encoded protein is a ligand of the epidermal growth factor receptor (EGFR) and the structurally related erb-b2 receptor tyrosine kinase 4 (ERBB4). The encoded protein may be involved in a wide range of biological processes including inflammation, wound healing, oocyte maturation, and cell proliferation. Additionally, the encoded protein may promote the progression of cancers of various human tissues. |
| UniProt Protein Function: | Epiregulin: Ligand of the EGF receptor/EGFR and ERBB4. May be a mediator of localized cell proliferation. As a mitogen it may stimulate cell proliferation and/or angiogenesis. |
| UniProt Protein Details: | Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: 4q13.3 Cellular Component: extracellular space; integral to plasma membrane; extracellular region Molecular Function:protein binding; growth factor activity; epidermal growth factor receptor binding Biological Process: response to peptide hormone stimulus; nerve growth factor receptor signaling pathway; wound healing; activation of MAPK activity; positive regulation of smooth muscle cell proliferation; positive regulation of interleukin-6 biosynthetic process; female meiosis; negative regulation of smooth muscle cell differentiation; negative regulation of cell proliferation; primary follicle stage, oogenesis; positive regulation of fibroblast proliferation; cell-cell signaling; positive regulation of epidermal growth factor receptor activity; positive regulation of cell proliferation; positive regulation of innate immune response; ovarian cumulus expansion; angiogenesis; negative regulation of epithelial cell proliferation; positive regulation of cytokine production; epidermal growth factor receptor signaling pathway; anatomical structure morphogenesis; fibroblast growth factor receptor signaling pathway; phosphoinositide-mediated signaling; positive regulation of mitosis; cytokine and chemokine mediated signaling pathway; positive regulation of cytokine biosynthetic process; luteinizing hormone signaling pathway; keratinocyte proliferation; oocyte maturation; keratinocyte differentiation; ovulation; organ morphogenesis; positive regulation of protein kinase activity; mRNA transcription; innate immune response; negative regulation of transcription, DNA-dependent; positive regulation of phosphorylation; positive regulation of DNA replication |
| NCBI Summary: | Epiregulin is a member of the epidermal growth factor family. Epiregulin can function as a ligand of EGFR (epidermal growth factor receptor), as well as a ligand of most members of the ERBB (v-erb-b2 oncogene homolog) family of tyrosine-kinase receptors. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O14944 |
| NCBI GenInfo Identifier: | 8134446 |
| NCBI Gene ID: | 2069 |
| NCBI Accession: | O14944.1 |
| UniProt Secondary Accession: | O14944,Q6FH69, B2RC66, |
| UniProt Related Accession: | O14944 |
| Molecular Weight: | 19,044 Da |
| NCBI Full Name: | Proepiregulin |
| NCBI Synonym Full Names: | epiregulin |
| NCBI Official Symbol: | EREG |
| NCBI Official Synonym Symbols: | ER |
| NCBI Protein Information: | proepiregulin |
| UniProt Protein Name: | Proepiregulin |
| Protein Family: | Proepiregulin |
| UniProt Gene Name: | EREG |
| UniProt Entry Name: | EREG_HUMAN |