Anti-EPS15 Antibody (CAB9814)
- SKU:
- CAB9814
- Product type:
- Antibody
- Application:
- WB
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
抗体名: | Anti-EPS15 Antibody |
抗体コード: | CAB9814 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB |
反応性: | Human, Mouse |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 660-840 of human EPS15 (NP_001972.1). |
申し込み: | WB |
推奨希釈: | WB 1:500 - 1:2000 |
反応性: | Human, Mouse |
ポジティブサンプル: | HeLa, Jurkat, 293T, NIH/3T3, Mouse liver, Mouse spleen, Mouse lung |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 660-840 of human EPS15 (NP_001972.1). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | RQST DPFA TSST DPFS AANN SSIT SVET LKHN DPFA PGGT VVAA SDSA TDPF ASVF GNES FGGG FADF STLS KVNN EDPF RSAT SSSV SNVV ITKN VFEE TSVK SEDE PPAL PPKI GTPT RPCP LPPG KRSI NKLD SPDP FKLN DPFQ PFPG NDSP KEKD PEIF CDPF TSAT TTTN KEAD P |
遺伝子ID: | 2060 |
Uniprot: | P42566 |
セルラーロケーション: | Cell membrane, Cytoplasm, Cytoplasmic side, Early endosome membrane, Membrane, Peripheral membrane protein, clathrin-coated pit |
計算された分子量: | 64kDa/98kDa |
観察された分子量: | 150kDa |
同義語: | EPS15, AF-1P, AF1P, MLLT5 |
バックグラウンド: | This gene encodes a protein that is part of the EGFR pathway. The protein is present at clatherin-coated pits and is involved in receptor-mediated endocytosis of EGF. Notably, this gene is rearranged with the HRX/ALL/MLL gene in acute myelogeneous leukemias. Alternative splicing results in multiple transcript variants encoding distinct isoforms. |
UniProt Protein Function: | Involved in cell growth regulation. May be involved in the regulation of mitogenic signals and control of cell proliferation. Involved in the internalization of ligand-inducible receptors of the receptor tyrosine kinase (RTK) type, in particular EGFR. Plays a role in the assembly of clathrin-coated pits (CCPs). Acts as a clathrin adapter required for post-Golgi trafficking. Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2. |
NCBI Summary: | This gene encodes a protein that is part of the EGFR pathway. The protein is present at clatherin-coated pits and is involved in receptor-mediated endocytosis of EGF. Notably, this gene is rearranged with the HRX/ALL/MLL gene in acute myelogeneous leukemias. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, May 2009] |
UniProt Code: | P42566 |
NCBI GenInfo Identifier: | 67476728 |
NCBI Gene ID: | 2060 |
NCBI Accession: | P42566.2 |
UniProt Secondary Accession: | P42566,Q5SRH4, B2R8J7, D3DPJ2, |
UniProt Related Accession: | P42566 |
Molecular Weight: | 99kDa |
NCBI Full Name: | Epidermal growth factor receptor substrate 15 |
NCBI Synonym Full Names: | epidermal growth factor receptor pathway substrate 15 |
NCBI Official Symbol: | EPS15 |
NCBI Official Synonym Symbols: | AF1P; AF-1P; MLLT5 |
NCBI Protein Information: | epidermal growth factor receptor substrate 15 |
UniProt Protein Name: | Epidermal growth factor receptor substrate 15 |
UniProt Synonym Protein Names: | Protein AF-1p |
Protein Family: | Epidermal growth factor receptor substrate |
UniProt Gene Name: | EPS15 |
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