Anti-EMR2 Antibody (CAB14278)
- SKU:
- CAB14278
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-EMR2 Antibody |
| 抗体コード: | CAB14278 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 300-500 of human EMR2 (NP_038475.2). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse |
| ポジティブサンプル: | K-562, LO2, A-549, HeLa, Mouse thymus, Mouse liver |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 300-500 of human EMR2 (NP_038475.2). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | TIQS ILQA LDEL LEAP GDLE TLPR LQQH CVAS HLLD GLED VLRG LSKN LSNG LLNF SYPA GTEL SLEV QKQV DRSV TLRQ NQAV MQLD WNQA QKSG DPGP SVVG LVSI PGMG KLLA EAPL VLEP EKQM LLHE THQG LLQD GSPI LLSD VISA FLSN NDTQ NLSS PVTF TFSH RSVI PRQK VLCV FWEH GQNG CGHW ATTG C |
| 遺伝子ID: | 30817 |
| Uniprot: | Q9UHX3 |
| セルラーロケーション: | Cell membrane, Cell projection, Multi-pass membrane protein, ruffle membrane |
| 計算された分子量: | 74kDa/80kDa/84kDa/85kDa/89kDa/90kDa |
| 観察された分子量: | 100kDa |
| 同義語: | ADGRE2, CD312, EMR2, VBU |
| バックグラウンド: | This gene encodes a member of the class B seven-span transmembrane (TM7) subfamily of G-protein coupled receptors. These proteins are characterized by an extended extracellular region with a variable number of N-terminal epidermal growth factor-like domains coupled to a TM7 domain via a mucin-like spacer domain. The encoded protein is expressed mainly in myeloid cells where it promotes cell-cell adhesion through interaction with chondroitin sulfate chains. This gene is situated in a cluster of related genes on chromosome 19. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. |
| UniProt Protein Function: | EMR2: Cell surface receptor that binds to the chondroitin sulfate moiety of glycosaminoglycan chains and promotes cell attachment. Promotes granulocyte chemotaxis, degranulation and adhesion. In macrophages, promotes the release of inflammatory cytokines, including IL8 and TNF. Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily. 5 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; GPCR, family 2; Membrane protein, multi-pass; Receptor, GPCR Chromosomal Location of Human Ortholog: 19p13.1 Cellular Component: plasma membrane; integral to membrane Molecular Function:G-protein coupled receptor activity; calcium ion binding Biological Process: G-protein coupled receptor protein signaling pathway; cell migration; inflammatory response; cell adhesion |
| NCBI Summary: | This gene encodes a member of the class B seven-span transmembrane (TM7) subfamily of G-protein coupled receptors. These proteins are characterized by an extended extracellular region with a variable number of N-terminal epidermal growth factor-like domains coupled to a TM7 domain via a mucin-like spacer domain. The encoded protein is expressed mainly in myeloid cells where it promotes cell-cell adhesion through interaction with chondroitin sulfate chains. This gene is situated in a cluster of related genes on chromosome 19. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2012] |
| UniProt Code: | Q9UHX3 |
| NCBI GenInfo Identifier: | 108935835 |
| NCBI Gene ID: | 30817 |
| NCBI Accession: | Q9UHX3.2 |
| UniProt Secondary Accession: | Q9UHX3,Q8NG96, Q9Y4B1, B4DQ96, E7ESD7, E9PBR1, E9PEL6 E9PFQ5, E9PG91, |
| UniProt Related Accession: | Q9UHX3 |
| Molecular Weight: | 90,472 Da |
| NCBI Full Name: | EGF-like module-containing mucin-like hormone receptor-like 2 |
| NCBI Synonym Full Names: | egf-like module containing, mucin-like, hormone receptor-like 2 |
| NCBI Official Symbol: | EMR2 |
| NCBI Official Synonym Symbols: | CD312 |
| NCBI Protein Information: | EGF-like module-containing mucin-like hormone receptor-like 2 |
| UniProt Protein Name: | EGF-like module-containing mucin-like hormone receptor-like 2 |
| UniProt Synonym Protein Names: | EGF-like module receptor 2 |
| UniProt Gene Name: | EMR2 |
| UniProt Entry Name: | EMR2_HUMAN |
 | Western blot analysis of extracts of various cell lines, using EMR2 Rabbit pAb (CAB14278) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s. |
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