Anti-EMP2 Antibody (CAB16327)
- SKU:
- CAB16327
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| 抗体名: | Anti-EMP2 Antibody |
| 抗体コード: | CAB16327 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human |
| 宿主種: | Rabbit |
| 免疫原: | A synthetic peptide corresponding to a sequence within amino acids 50-150 of human EMP2 (NP_001415.1). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human |
| ポジティブサンプル: |
| 免疫原: | A synthetic peptide corresponding to a sequence within amino acids 50-150 of human EMP2 (NP_001415.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | VIND SFQE YSTL QAVQ ATMI LSTI LCCI AFFI FVLQ LFRL KQGE RFVL TSII QLMS CLCV MIAA SIYT DRRE DIHD KNAK FYPV TREG SYGY SYIL AWVA F |
| 遺伝子ID: | 2013 |
| Uniprot: | P54851 |
| セルラーロケーション: | |
| 計算された分子量: | 19kDa |
| 観察された分子量: | Refer to figures |
| 同義語: | EMP2, XMP |
| バックグラウンド: | This gene encodes a tetraspan protein of the PMP22/EMP family. The encoded protein regulates cell membrane composition. It has been associated with various functions including endocytosis, cell signaling, cell proliferation, cell migration, cell adhesion, cell death, cholesterol homeostasis, urinary albumin excretion, and embryo implantation. It is known to negatively regulate caveolin-1, a scaffolding protein which is the main component of the caveolae plasma membrane invaginations found in most cell types. Through activation of PTK2 it positively regulates vascular endothelial growth factor A. It also modulates the function of specific integrin isomers in the plasma membrane. Up-regulation of this gene has been linked to cancer progression in multiple different tissues. Mutations in this gene have been associated with nephrotic syndrome type 10 (NPHS10). |
| UniProt Protein Function: | EMP2: Belongs to the PMP-22/EMP/MP20 family. |
| UniProt Protein Details: | Protein type:Membrane protein, multi-pass; Membrane protein, integral Chromosomal Location of Human Ortholog: 16p13.2 Cellular Component: apical part of cell; caveola; cell surface; cytoplasm; cytoplasmic vesicle; Golgi apparatus; lipid raft; nucleus; plasma membrane Molecular Function:integrin binding; kinase binding; protein binding; protein kinase binding Biological Process: actin filament organization; activation of protein kinase activity; bleb formation; blood vessel endothelial cell migration; cell adhesion; cell death; cell migration; cell proliferation; cell-matrix adhesion; early endosome to late endosome transport; embryo implantation; lipid raft formation; positive regulation of cell proliferation; positive regulation of cell-matrix adhesion; regulation of angiogenesis; regulation of glomerular filtration; regulation of kinase activity; T cell mediated cytotoxicity Disease: Nephrotic Syndrome, Type 10 |
| NCBI Summary: | This gene encodes a tetraspan protein of the PMP22/EMP family. The encoded protein regulates cell membrane composition. It has been associated with various functions including endocytosis, cell signaling, cell proliferation, cell migration, cell adhesion, cell death, cholesterol homeostasis, urinary albumin excretion, and embryo implantation. It is known to negatively regulate caveolin-1, a scaffolding protein which is the main component of the caveolae plasma membrane invaginations found in most cell types. Through activation of PTK2 it positively regulates vascular endothelial growth factor A. It also modulates the function of specific integrin isomers in the plasma membrane. Up-regulation of this gene has been linked to cancer progression in multiple different tissues. Mutations in this gene have been associated with nephrotic syndrome type 10 (NPHS10). [provided by RefSeq, Mar 2015] |
| UniProt Code: | P54851 |
| NCBI GenInfo Identifier: | 1706643 |
| NCBI Gene ID: | 2013 |
| NCBI Accession: | P54851.1 |
| UniProt Secondary Accession: | P54851,B2R7V6, D3DUF8, |
| UniProt Related Accession: | P54851 |
| Molecular Weight: | 19,199 Da |
| NCBI Full Name: | Epithelial membrane protein 2 |
| NCBI Synonym Full Names: | epithelial membrane protein 2 |
| NCBI Official Symbol: | EMP2 |
| NCBI Official Synonym Symbols: | XMP |
| NCBI Protein Information: | epithelial membrane protein 2 |
| UniProt Protein Name: | Epithelial membrane protein 2 |
| UniProt Synonym Protein Names: | Protein XMP |
| Protein Family: | Epithelial membrane protein |
| UniProt Gene Name: | EMP2 |
| UniProt Entry Name: | EMP2_HUMAN |