| UniProt Protein Function: | ELK1: a transcription factor of the Ets family and the ternary complex factor (TCF) subfamily. Forms a ternary complex by binding to the serum response factor and the serum response element in the promoter of the c-fos proto-oncogene. Mediates gene activity in response to serum and growth factors. Phosphorylated by MAP kinase pathways at a cluster of S/T motifs at its C-terminus; phosphorylation at these sites is critical for transcriptional activation by Elk-1. Two alternatively-spliced isoforms have been described. |
| UniProt Protein Details: | Protein type:Transcription factor; DNA-binding Chromosomal Location of Human Ortholog: Xp11.2 Cellular Component: cell soma; dendrite; mitochondrion; nerve terminal; nucleoplasm; nucleus Molecular Function:chromatin binding; protein binding; transcription factor activity Biological Process: cell differentiation; innate immune response; MyD88-dependent toll-like receptor signaling pathway; MyD88-independent toll-like receptor signaling pathway; nerve growth factor receptor signaling pathway; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; response to light stimulus; stress-activated MAPK cascade; toll-like receptor 10 signaling pathway; toll-like receptor 2 signaling pathway; toll-like receptor 3 signaling pathway; toll-like receptor 4 signaling pathway; toll-like receptor 5 signaling pathway; toll-like receptor 9 signaling pathway; toll-like receptor signaling pathway; transcription from RNA polymerase II promoter |
| NCBI Summary: | This gene is a member of the Ets family of transcription factors and of the ternary complex factor (TCF) subfamily. Proteins of the TCF subfamily form a ternary complex by binding to the the serum response factor and the serum response element in the promoter of the c-fos proto-oncogene. The protein encoded by this gene is a nuclear target for the ras-raf-MAPK signaling cascade. This gene produces multiple isoforms by using alternative translational start codons and by alternative splicing. Related pseudogenes have been identified on chromosomes 7 and 14. [provided by RefSeq, Mar 2012] |
| UniProt Code: | P19419 |
| NCBI GenInfo Identifier: | 12643407 |
| NCBI Gene ID: | 2002 |
| NCBI Accession: | P19419.2 |
| UniProt Secondary Accession: | P19419,O75606, O95058, Q969X8, Q9UJM4, B2R7H4, |
| UniProt Related Accession: | P19419 |
| Molecular Weight: | |
| NCBI Full Name: | ETS domain-containing protein Elk-1 |
| NCBI Synonym Full Names: | ELK1, ETS transcription factor |
| NCBI Official Symbol: | ELK1 |
| NCBI Protein Information: | ETS domain-containing protein Elk-1 |
| UniProt Protein Name: | ETS domain-containing protein Elk-1 |
| Protein Family: | ETS domain-containing protein |
| UniProt Gene Name: | ELK1 |
| UniProt Entry Name: | ELK1_HUMAN |
