Anti-EIF5A Antibody (CAB2016)
- SKU:
- CAB2016
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Epigenetics and Nuclear Signaling
Description
抗体名: | Anti-EIF5A Antibody |
抗体コード: | CAB2016 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB IHC IF |
反応性: | Human, Mouse |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-154 of human EIF5A (NP_001137234.1). |
申し込み: | WB IHC IF |
推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
反応性: | Human, Mouse |
ポジティブサンプル: | HeLa, 293T, Raji, 22Rv1, HepG2, K-562, U-251MG, Mouse liver, Mouse testis |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-154 of human EIF5A (NP_001137234.1). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | MADD LDFE TGDA GASA TFPM QCSA LRKN GFVV LKGR PCKI VEMS TSKT GKHG HAKV HLVG IDIF TGKK YEDI CPST HNMD VPNI KRND FQLI GIQD GYLS LLQD SGEV REDL RLPE GDLG KEIE QKYD CGEE ILIT VLSA MTEE AAVA IKAM AK |
遺伝子ID: | 1984 |
Uniprot: | P63241 |
セルラーロケーション: | Cytoplasm, Cytoplasmic side, Endoplasmic reticulum membrane, Nucleus, Peripheral membrane protein, nuclear pore complex |
計算された分子量: | 16kDa/20kDa |
観察された分子量: | 17kDa |
同義語: | EIF5A, EIF-5A, EIF5A1, eIF5AI |
バックグラウンド: |
UniProt Protein Function: | EIF5A: mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. With syntenin SDCBP, functions as a regulator of p53/TP53 and p53/TP53-dependent apoptosis. Regulates also TNF- alpha-mediated apoptosis. Mediates effects of polyamines on neuronal process extension and survival. May play an important role in brain development and function, and in skeletal muscle stem cell differentiation. Also described as a cellular cofactor of human T-cell leukemia virus type I (HTLV-1) Rex protein and of human immunodeficiency virus type 1 (HIV-1) Rev protein, essential for mRNA export of retroviral transcripts. Belongs to the eIF-5A family. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Translation initiation; Translation Chromosomal Location of Human Ortholog: 17p13-p12 Cellular Component: endoplasmic reticulum membrane; membrane; cytoplasm; nuclear pore; cytosol; nucleus; annulate lamellae Molecular Function:protein binding; RNA binding; ribosome binding; protein N-terminus binding; translation elongation factor activity; U6 snRNA binding Biological Process: mRNA export from nucleus; translational frameshifting; cellular protein metabolic process; apoptosis; positive regulation of cell proliferation; nucleocytoplasmic transport; positive regulation of translational elongation; hypusine biosynthetic process from peptidyl-lysine; protein export from nucleus; post-translational protein modification; positive regulation of translational termination |
UniProt Code: | P63241 |
NCBI GenInfo Identifier: | 54037409 |
NCBI Gene ID: | 1984 |
NCBI Accession: | P63241.2 |
UniProt Related Accession: | P63241 |
Molecular Weight: | ~ 18kDa |
NCBI Full Name: | Eukaryotic translation initiation factor 5A-1 |
NCBI Synonym Full Names: | eukaryotic translation initiation factor 5A |
NCBI Official Symbol: | EIF5A |
NCBI Official Synonym Symbols: | EIF-5A; EIF5A1; eIF-4D; eIF5AI |
NCBI Protein Information: | eukaryotic translation initiation factor 5A-1 |
UniProt Protein Name: | Eukaryotic translation initiation factor 5A-1 |
UniProt Synonym Protein Names: | Eukaryotic initiation factor 5A isoform 1; eIF-5A; Rev-binding factor; eIF-4D |
Protein Family: | Translation initiation factor |
UniProt Gene Name: | EIF5A |
UniProt Entry Name: | IF5A1_HUMAN |